CD Bioparticles uses a 1st or 3rd generation adenovirus vector packaging system to provide customers with high-quality adenovirus, helping you for gene therapy and scientific research. We have developed a range of techniques and reagents that have greatly improved the titer, purity, viability, and consistency of adenovirus vector services. At the same time, we can also provide you with a series of toxicological experiments and biodistribution experimental research services to meet your scientific research requirements.
Adenovirus (Ads) are non-enveloped viruses containing a 35-36 kb linear double-stranded DNA genome inside an icosahedral virion of 70-90 nm in diameter. The adenovirus genome is characterized by inverted terminal repeats (ITR) and several early (E) and late (L) genes. Adenovirus vectors (AdVs) are assembled with empty capsids, packaging proteins and the target gene. AdVs systems have high transduction efficiency in both quiescent and dividing cells, persistence in the targeted cells; broad tissue, and easy to scale-up production. Thus, AdVs are the most applied vectors for cancer gene therapy. Currently, AdV is updated to 3rd generation and “high-capacity” adenoviral vectors (HCAds). HCAds have lower immunogenicity, a longer transduction time window and more transgene cassettes/genes than those of early generation vectors.
The packaging process of adenovirus is shown in Figure 1:
Figure 1. Adenovirus Vectors Production.
These are just a few examples of the many applications of AdVs.
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We would be glad to discuss your project in more detail with our support team if you would like more information.