Auricular Administration

Introduction of Auricular Administration

Auricular administration is the process of delivering medication to the body through the ear. It entails either administering medication topically to the ear's surface or injecting it directly into the ear's tissues.

The Application of Auricular Administration

• Diseases Suitable for Auricular Administration

Numerous ear-related disorders, such as infections, inflammation, and pain, can be treated with auricular administration. It can also be used to treat ailments like nausea or anxiety that affect other body areas.

• Nano-delivery Products and Clinical Cases of Auricular Administration

The effectiveness and safety of auricular administration can be improved by using nanoparticles. Nanoparticles, for instance, can be utilized to encapsulate medications, shield them from deterioration, boost their bioavailability, and distribute them specifically to target regions. For auricular administration, a number of nano-delivery systems have been created, including nanoemulsions, nanogels, and nanoliposomes.

Auricular administration with nano-delivery products has been used in a number of clinical cases, according to reports. For instance, a study described the creation of an auricular formulation of the anti-inflammatory medication dexamethasone based on nanoemulsion technology. According to the study, using a nanoemulsion may be a potential strategy for treating ear inflammation because it enhanced drug absorption and retention in the ear.

Characteristics of Auricular Administration

• Auricular Administration Benefits

The fact that auricular administration is a non-invasive drug delivery approach is one of its main benefits. Auricular administration does not involve skin piercing, unlike injections or other invasive procedures. For many people, this makes it a more cozy and practical choice.

Figure 1. Principles of substance distribution in the inner ear. (Salt AN, et al.; 2009)

Auricular administration also has the benefit of being a targeted delivery strategy. Medication can be administered particularly to the tissues and structures of the ear by administering it directly to it. This is particularly beneficial for treating ear-related disorders including inflammation or infections.

• Auricular Administration Drawbacks

It can be challenging to administer precisely, which is one of the main drawbacks of auricular administration. Applying medication to the wrong part of the complicated and small ear might be damaging or useless. For healthcare practitioners, this might make auricular administration a difficult drug delivery strategy.

Auricular administration has the additional drawback of not being appropriate for all medications. Some medicines might not be effectively absorbed via the ear skin or might break down too quickly. The variety of conditions that can be treated with auricular administration may be constrained as a result.

• Biology of Auricular Administration Barriers

Biological barriers that can impair drug absorption and effectiveness are present during auricular delivery. Drugs may have trouble penetrating the comparatively thick skin of the ear, especially if they include big or hydrophilic compounds. Cerumen (earwax), which coats the ear canal, can also prevent drugs from being absorbed. In addition, the blood arteries in the ear are relatively few, which may restrict how far medications are distributed throughout the body.

• Nanoparticles' Function in Auricular Administration

In auricular administration, nanoparticles can take on a number of significant roles. They can give tailored distribution to particular tissues and enhance medication solubility, stability, and bioavailability. Nanoparticles can also be utilized to regulate drug release and enhance the safety and effectiveness of medications.

Our Featured Services

CD Bioparticles is specialized in the development of drug delivery systems and customizing nanoparticles for drug delivery utilizing our core technologies. With our high-quality products and services, the efficacy of your drug delivery can be tremendously improved.

We offer custom synthesis of polymer microspheres and nanoparticles. Clients may select the material type, particle size, size distribution, color dye, fluorescent dye, and/or surface functional groups such as carboxyl or amine groups. We also encapsulate proteins, steroids, ligands, nucleic acids, and other drug molecules. Additionally, the surface coating of microspheres or nanoparticles with ligands, oligonucleotides, and other agents are available for clients to choose.

References

1. Ceccherelli F, et al.; The effect of benzodiazepines administration on auricular symptomatological evidence. Acupunct Electrother Res. 1990,15(2):95-106.
2. Salt AN, Plontke SK. Local inner-ear drug delivery and pharmacokinetics. Drug Discov Today. 2005,10(19):1299-306.
3. Plontke SK, Salt AN. Local drug delivery to the inner ear: Principles, practice, and future challenges. Hear Res. 2018, 368:1-2.
4. Salt AN, Plontke SK. Principles of local drug delivery to the inner ear. Audiol Neurootol. 2009;14(6):350-60.