Biodegradable Polymers

CD Bioparticles’ products with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Limited options for the bio-conjugation between macromolecules and biomolecules
• Unpredictable or uncontrollable degradation rate of the drug-loading cargo
• Uncontrollable drug delivery profile
• Biomolecules denatured during the conjugation
• Limited options for material solidification which limits the choice of the materials for additive manufacturing precision medicine
• Tedious chemical synthesis and purifications

Key Features

• Dextrans and derivatives
  • Amine functionalized
  • Biotin conjugated
  • Aldehyde functionalized
  • Azide functionalized
  • DBCO functionalized
  • Lysine conjugated
  • Thiol functionalized
  • Maleimide conjugated
  • Vinyl sulfone functionalized
  • Carboxylate functionalized
  • IgG conjugated
• Chitosans and derivatives
  • 85% - 95% DDA, various water solubility
  • Biotin conjugated
  • Chitin-Glycol
• Polylactides (PLA) and derivatives
  • Enantiomers
  • Amine terminal
  • Diacrylate
  • Maleimide terminal
  • Thiol terminal
  • Glycerol conjugated
  • Butanol terminal
  • Decanol terminal
  • Glucose terminal
• Poly(caprolactone)s (PCL) and derivatives
  • Dihydrazide functionalized
  • Cholesterol functionalized
  • Dihydroxyl terminal
  • Trihydroxyl terminal
  • Dimethacrylate terminal

• Poly(lactic-co-glycolic acid)s (PLGA) and derivatives
  • Various PLA:PGA ratio
  • Enantiomers
  • Dihydrazide terminal
  • Dimethacrylate
  • Amine & Diamine terminal
  • Thiol & Dithiol terminal
  • NHS terminal
  • Histidine terminal
  • Carboxylic acid & dicarboxylic acid terminal
  • Maleimide terminal
  • Biotin terminal
  • Dihydroxyl
  • Glucose terminal
  • Cholesterol terminal
  • 3-arm trimethylolpropane Initiated
  • 4-arm pentaerithrytol initiated
  • 5-arm adonitol initiated
  • 6-arm dipentaerithrytol initiated
• Poly(N-isopropylacrylamide) (PNIPAM) Copolymers
  • NHS functionalized
  • Polyacrylic acid copolymer
  • Polymethacrylate copolymer
  • Polyacrylamide copolymer
  • mPEG copolymer
• Poly(Lactide-co-caprolactone)s (PLCL)
  • Enantiomer
• Poly(glycolide-co-caprolactone)s
• Poly(lactide-co-trimethylene carbonate)s
• Agar
• Pectin
• Ficolls
• Agarose
• Dendrons
• Heparins
• Alginates
• Dendrimers
• Celluloses
• Xanthan Gum
• Polylactides
• Carrageenans
• Alginic Acids
• D-Glucosamines
• Locust Bean Gum
• Hyaluronic Acids
• Chondroitin Sulfates
• Other Polysaccharides
• Oligomeric Hyaluronic Acids
• Poly(glycolide)s
• Other Polymers
  • Polycarbonate and derivatives
  • Poly(carbonate-co-caprolactone) and derivatives
  • Polyelectrolytes and derivatives (Polycations and polyanions)
  • Pluronic based poly(urethane)
  • Poly(dioxane) and derivatives
  • Vinyl side chain based
  • Polypeptide and Polynucleotides
  • Polyurathane and derivatives
  • Polydimethylsiloxane and derivatives
  • Hyaluronic acid and derivatives
  • Cellulose and derivatives
  • Alginate and derivatives
  • Collagen
  • Fibrinogen and fibrin
  • Polyphenol and derivatives
  • Silk
  • Bioglass
  • Gelatin and derivatives

Key benefits:

• Wide coverage of the biomaterials with different physical properties, such as Tg, Tm, shear viscosity, Young’s modulus, dielectric constant, matching your customized biomaterial processing conditions and the requirements of the final products
• Various of solidification of the materials useful for additive manufacturing of precision medicine
• Wide coverage of the functionalized biomolecules, useful for your customized conjugation, modification, crosslinking applications
• Precise formulation of the polymer components to control the degradation time useful for different drug delivery and bio-graft applications
• Efficient conjugation reactions in the ambient condition to prevent the protein denatured
• Temperature-responsive solubility of the biomaterials in aqueous solution with controllable transition temperatures, such as different UCST and LCST

Application candidates:

• Drug-delivery cargos with controllable delivery profile
• Active biomaterials with various of ready-to-use bio-conjugation options
• Hydrogels with sol-gel transition useful for reversible encapsulation and delivery
• Bioadhesives with controllable adhesion forces for wound healing and drug delivery
• Additive manufacturing of precision medicine by means of hot melt extrusion, solution extrusion, photo-stereolithography, inkjet printing