Adjuvants

Based on hydrophilic and lipophilic properties of adjuvants, they are often used in vaccine delivery systems. They can reduce the toxicity of vaccines and increase immune activity. CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Drug delivery models is unstable of thermodynamics in vitro or in vivo studies
• Complicated formulation of the drug-loaded liposomes with optimized loading yield of different drug molecules
• Subunit vaccines have poor immunogenicity
• The loading rate of hydrophilic drugs is low
• Tedious drug-loaded liposome formulation, purifications, and production

Key features:

• 22:0 Trehalose
• 3A-MPLA
• 3D- (6-acyl) PHAD®
• 3D-PHAD®
• 4A-MPLA
• MPLA (PHAD®)
• PHAD®-504

Key benefits:

• Surface active liposomes allowing the modification of the drug-loaded liposomes to achieve cell-targeting or tissue-targeting
• Post-drug-loading liposomes allowing customized drug loading
• Increase the solubility of the encapsulated drug
• Improved stability over other drug solubility vehicles
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• Drug delivery models of in vitro or in vivo studies
• Initiating antigen uptake
• Cell-targeting or tissue targeting drug delivery
• Promote the development of a predominantly cell-or antibody-mediated response
• Protects antigens (especially DNA and RNA) from being broken down by enzymes in the body
• Change the type of circulating antibodies produced
• Increase circulating antibody levels or produce more effective protective immunity