Bacterial Lipids

Fatty acids and phospholipids occur in a wide variety of structures in nature, and the ability to alter their composition in response to environmental changes is essential for bacterial survival. While E. coli has been considered a model for lipid synthesis and metabolism in bacteria for decades, modern genome sequencing has revealed that the regulation of metabolic pathways must be investigated on a species-specific basis. Therefore, understanding basic lipid metabolism and enzyme pathways in prokaryotes needs to be based on different strains, and bacterial lipids will be studied more extensively.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• The lipid-metabolizing genes and enzymes in E. coli are not common to all bacteria
• Lipid metabolism pathway is complex and the synthesis of intermediates is difficult
• Lipids cannot be modified for a wider range of uses
• Signal control performance is not accurate
• Bacterial fatty acid regulation and biosynthesis mechanisms are incredibly diverse
• Fatty acid synthesis is an energy-intensive process

Key features:

• Mycolic Acids A long chain fatty acid located in the cell wall of Mycobacterium
• Branched Lipids
• Cyclopropyl Lipids
• N-acylhomoserine lactone (AHL) Signaling molecules involved in quorum sensing in bacteria

Key benefits:

• Inducing a strong protective immune response
• Phospholipid bilayer can be modified by physical and chemical methods
• Stabilizing proteins or acting as bioreactors
• Easy to prepare
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• To discover new lipid synthesis and metabolic pathways in bacteria
• Make bacterial membrane lipids and act as precursors for acylated proteins
• As a target for the development of new antibacterial compounds
• To treat bacterial biofilm infections
• To study the mechanism of bacterial resistance to antibiotics
• Study intraspecific and interspecific communication between bacteria