Click Reagents

Click chemistry holds some promise for making it easier to connect synthetic molecular fragments to make larger, more complex molecular structures. The click reaction must exhibit properties such as modularity, broad range, high yield, and stereospecificity, and produce few or no byproducts that can be removed by non-chromatic methods. CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• The yield of reaction product is low
• Bioconjugation has a low yield and produces harmful by-products
• The separation of reaction products is difficult
• The drug itself has serious side effects
• The concentration of the drug at the target site is low
• The reaction is incomplete due to the spatial inaccessibility of the reaction sites in the polymer structure
• Lesions in rare cancers are difficult to image
• Chemical reactions do not yield quantitative quantities of products

Key features:

• 16:0 Azido Coenzyme A
• 16:0 azidocaproyl PE
• 16:0 Azidoethyl SM (d18:1/16:0)
• 16:0 DBCO PE
• 16:0 hexynoyl PE
• 16:0 propargyl SM (d18:1-16:0)
• 16:0(alkyne)-18:1 PC
• 16:0(alkyne)-18:1 PE
• 18:0 azidoethyl PC
• 18:0 propargyl PC
• 18:1 DBCO PE
• 18:1 propargyl PC
• 27-alkyne cholesterol
• Alkyne-cholesterol
• Arachidonic acid-alkyne
• Azido sphingosine (d14:1)
• C6(6-azido) Ceramide
• C6(6-azido) GalCer
• C6(6-azido) GluCer
• C6(6-azido) LacCer
• Click PI (4,5) P2-azido
• DSPE-PEG (2000) Azide
• DSPE-PEG (2000)-DBCO
• N3C14SOBRAC
• Oleic Acid (18-azido)
• Oleic acid(17-yne)
• Palmitic acid (15-yne)
• PhotoClick Cholesterol
• PhotoClick Sphingosine
• Photoclick Sphingosine-1-Phosphate

Key benefits:

• Improve the selectivity of drugs to cancer cells
• Improve the stability of the drug delivery system
• Rapid construction of complex organic molecules
• The small molecules used as starting materials have simple structures
• Almost no side effects occur
• The reaction can take place in water
• Simple operation, selective, low cost
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• Tagging of live organisms and proteins
• Imaging test in vivo
• Activity-based protein profiling (ABPP)
• Labeling of DNA
• For more rare cancers
• Development of new catalysts
• Drug discovery and high-throughput screening
• Construction of unnatural amino acid modules