Coenzyme A and Derivatives

Coenzyme A (CoA) is an essential cofactor in various enzymatic reactions related to metabolism. It comprises of a nucleotide (adenosine monophosphate), a pantothenic acid molecule, and a mercaptoethylamine group. CoA is known to activate carboxylic acids, so it is involved in fatty acid oxidation, amino acid catabolism, and various other metabolic pathways. It plays a vital role in the Krebs cycle by mediating the transfer of acetyl and succinyl groups. CoA derivatives such as acetyl-CoA and succinyl-CoA serve as critical metabolites in generating energy and are therefore critical components of several important pathways in organisms. Acetyl-CoA, for instance, is the end product of the breakdown of carbohydrates, lipids, and amino acids, and serves as the starting substrate for the Krebs cycle. In summary, CoA and its derivatives play crucial roles in energy metabolism, and their dysfunction.

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • There are many health problems related to metabolism and energy production
  • The lipid metabolism pathway of various regulatory factors is not clear
  • Drug metabolism in the body is too slow resulting in residual toxicity
  • Tedious liposome formulation, purifications, and production

Key features:

Key benefits:

  • To help the transfer of acyl groups
  • Enhance metabolic pathways and energy production
  • Reduce the toxicity and side effects of drugs and improve their efficacy
  • Simple operation, selective, low cost
  • Suitable for in vitro and in vivo experiments
  • Ready-to-use

Application candidates:

  • Study on various biological processes such as fatty acid metabolism, amino acid metabolism, cholesterol and steroid synthesis
  • Used to produce antibiotics and other drugs
  • Used in the development of anti-aging creams because of its oxidative properties
  • Prevention and treatment of multiple metabolic diseases, including type 2 diabetes, obesity and cardiovascular disease
  • Improve cognitive function and reduce fatigue
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