Detergents

Based on amphipathic properties of detergents, they can be used to build delivery systems for hydrophilic drugs as well as lipophilic drugs. Detergents can be used to extract membrane proteins and maintain the integrity of membrane proteins in the process of protein purification. CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Aggregation or denaturation of membrane proteins
• Structural and functional representations of integrated membrane proteins are incompatible
• Lack of systematic and efficient screening method for detergents
• Drugs with low bioavailability are difficult to deliver
• Complicated formulation of the drug-loaded liposomes with optimized loading yield of different drug molecules
• Strong immune response or foreign body response of your materials
• Tedious drug-loaded liposome formulation, purifications, and production

Key features:

• Anionic Detergents Carboxylate, sulfonate, sulfate salt and phosphate salt
• Cationic Detergents Organic amine derivative
• Nonionic Detergents Hydrophilic groups do not dissociate in aqueous solution
• Branched Detergents
• Zwitterionic Detergents Dissolve membrane-bind proteins
• Lipid Mesophase Crystallization New lipid detergent

Key benefits:

• Surface active liposomes allowing the modification of the drug-loaded liposomes to achieve cell-targeting or tissue-targeting
• Post-drug-loading liposomes allowing customized drug loading
• Construction of safe, effective and friendlier drug delivery systems
• Improved stability over other drug solubility vehicles
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• Drug delivery models of in vitro or in vivo studies
• Membrane protein extraction
• To maintain the integrity of membrane proteins during purification
• High concentrations dissolve cell membranes in the process of protein purification
• Construct proteins on phospholipid bilayers
• Reconstitution of membrane proteins in lipid vesicles
• Delivery of drugs with low bioavailability
• Cell-targeting or tissue targeting drug delivery