Branched Detergents

Branched detergents, also known as amphiphilic or surfactant molecules, have been found to have potential in drug delivery. These molecules are composed of a hydrophobic (water-repelling) tail and a hydrophilic (water-attracting) head, allowing them to interact with both water and nonpolar substances such as lipids. They solubilize hydrophobic drugs by forming micelles and enable drug delivery across biological membranes, including the blood-brain barrier. Branched detergents can also target specific cells or tissues through modifications to their hydrophilic head. Overall, the use of branched detergents in drug delivery shows promise for improving the solubility and delivery of hydrophobic drugs, as well as targeted delivery to specific cells or tissues.

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Hydrophobic drugs are difficult to deliver into the body
• Drugs have difficulty crossing biological membranes, such as the blood-brain barrier
• Drug concentration at the target site is low
• Drugs with low bioavailability are difficult to deliver
• Strong immune response or foreign body response of drugs
• Tedious drug-loaded liposome formulation, purifications, and production

Key benefits:

• Surface active liposomes allowing the modification of the drug-loaded liposomes to achieve cell-targeting or tissue-targeting
• To dissolve hydrophobic drugs
• Encapsulation of the drug by the formation of micelles and allowing drug transport in vivo
• Post-drug-loading liposomes allowing customized drug loading
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• Drug delivery models of in vitro or in vivo studies
• Used as a solubilizer to improve the solubility and bioavailability of poorly soluble drugs
• Formulations for personal care products such as shampoos, conditioners and lotions
• For the purification and isolation of proteins, enzymes and other biological molecules
• Used to clean up oil spills to disperse and promote their biodegradation