Zwitterionic Detergents

Zwitterionic detergents are a type of surfactant that have both positively and negatively charged groups in their chemical structure. One advantage of zwitterionic detergents is that they are highly water-soluble and biocompatible, which reduces the risk of toxicity and allergic reactions when used in drug delivery. They are also less likely to interfere with drug activity since they are less prone to denature proteins or alter membrane structure. These detergents can effectively increase the bioavailability of hydrophobic drugs by forming micelles that can encapsulate the drug molecules, protecting them from degradation and improving their pharmacokinetic properties.

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Drugs may cause severe allergic reactions
• The drug carrier molecule denatures the protein or changes the membrane structure
• Therapeutic drugs may be degraded quickly in the body
• Drugs with low bioavailability are difficult to deliver
• Tedious drug-loaded liposome formulation, purifications, and production

Key benefits:

• Improved stability over other drug solubility vehicles
• Low immunogenicity and low toxicity
• Micelles are formed to protect the drug molecules from degradation
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• Drug delivery models of in vitro or in vivo studies
• Protein purification
• As an additive in cell culture media to help protect cells from damage caused by shear forces
• For the design of biosensors to improve the selectivity of the sensors by reducing non-specific binding to the sensor surface
• In a variety of biophysical studies, including surface plasmon resonance, isothermal titration calorimetry, and small-angle neutron scattering
• To study the interactions between cells and immune systems