Fluorescent Phospholipids

Fluorescent phospholipids are synthetic or naturally occurring lipids that have been attached with a fluorescent dye or tag. These molecules are used to study the dynamics and movement of lipids within cell membranes. The fluorescent tag on the lipid enables researchers to visually track lipids in live-cell imaging experiments. Fluorescent phospholipids are used to investigate cellular events like membrane fusion, secretion, and endocytosis. They also provide insight into lipid trafficking and lipid-dependent signaling pathways. One notable example of a fluorescent phospholipid is the green fluorescent protein (GFP) attached to phosphatidylethanolamine. These molecules are invaluable tools in the development of future treatments for diseases that have an impact on the cellular processes that lipids play a role in, such as cancer and neurodegenerative disorders.

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Hard to track and image the distribution of the lipids
• The concentration of the drug at the target site is low
• The lipid signaling pathway and mechanism remain unclear
• Invasive probes can cause unexpected damage to cells
• Chemotherapy drugs for cancer are usually more toxic to the body
• Tedious chemical synthesis, formulation, and purifications

Key benefits:

• Compared with traditional fluorescent dyes, they have the key advantages of higher spectral resolution, higher specificity and non-invasiveness
• Good biocompatibility and low immunogenicity
• The location of the fluorescence emission can be used to assess local biofilm properties such as polarity and fluidity
• Drug-loaded or non-loading fluorescent liposomes for positive control and negative control of your drug delivery tests
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• For cancer and neurodegenerative diseases
• Used as a probe to study the structure and function of cell membranes
• Used as a tool to monitor intracellular lipid transport and signal transduction pathways
• Useful tools for studying various cellular processes, including membrane fusion, endocytosis, and exocytosis
• Used to study the behavior of lipid bilayer as membrane simulators and the behavior of proteins interacting with membranes