Chelators are widely present in living systems and play an important role in cell metabolism. Chelation is the combination of ions and molecules with metallic ions. It involves the formation or presence of two or more separate coordinate bonds between a multi-toothed (multi-bond) ligand and a single central metal atom. The chelator liposomes are easy to metabolize, less toxic, and excreted in the urine. Macromolecular chelators often have a long half-life, which can reduce the frequency of administration and relieve the patient's pain.

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • Chelate metal has short half-life and high toxicity and side effects
  • Chelating agents have low bioavailability and are prone to drug resistance
  • Active groups and chelated metal ions are unstable by ionic bonding, and a large amount of drugs are lost in systemic circulation
  • The abnormal metabolism of metal ions in tumor tissues may have a high concentration of metal ions
  • The concentration of the drug at the tumor site is low
  • Tedious liposome formulation, purifications, and production

Key benefits:

  • Increase efficacy and therapeutic index of the entrapped drug
  • Increase the half-life and bioavailability of the drug
  • Easy to metabolize and less toxic
  • Improved stability over other drug solubility vehicles
  • Suitable for in vitro and in vivo experiments
  • Ready-to-use

Application candidates:

  • For rheumatoid arthritis and other diseases
  • As a nutrient solution for microorganisms and plants in aquaculture
  • As an additive to animal food to prevent the precipitation or absorption of essential metals
  • As anti-jamming agent for the determination of intracellular cation concentration
  • To measure cell viability
Product Name Catalog Form Unit Size Price
16:0 PE-DTPA CDLP-A499 Powder 5 mg INQUIRY
16:0 PE-DTPA (Gd) CDLP-A479 Powder 5 mg INQUIRY
18:0 PE-DTPA CDLP-A492 Powder 5 mg INQUIRY
18:0 PE-DTPA (Gd) CDLP-A496 Powder 5 mg INQUIRY
18:1 DGS-NTA CDLP-A497 Powder or Chloroform 5 mg INQUIRY
18:1 DGS-NTA(Co) CDLP-A498 Powder 5 mg INQUIRY
18:1 DGS-NTA(Ni) CDLP-A500 Powder or Chloroform 5 mg INQUIRY
bis(14:0 PE)-DTPA (Gd) CDLP-A494 Powder 5 mg INQUIRY
bis(16:0 PE)-DTPA (Gd) CDLP-A493 Powder 5 mg INQUIRY
bis(18:0 PE)-DTPA (Gd) CDLP-A490 Powder 5 mg INQUIRY
DTPA-BSA (Gd) CDLP-A495 Powder 100 mg INQUIRY
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