pH Sensitive Lipids

pH-sensitive lipids are liposomes that are sensitive to the pH environment. The stability of lipid bilayers in their structure varies with environmental pH and can also be referred to as acid-sensitive liposomes. In tumor interstitial fluid, ischemic areas, and areas of infection or inflammation, the pH is significantly lower than that of the surrounding normal tissue, and abnormal acidification occurs. Researchers have developed pH-sensitive lipids based on changes in pH in the physiological environment of pathological tissues. pH-sensitive lipids not only reduce the degradation of drugs by enzymes in the lysosome to a certain extent, but also improve the stability and uptake of the contents and efficiently transport drugs to the cytoplasm and diseased tissues.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Drugs and gene fragments are easily degraded by lysosomal enzymes
• The stability of drugs in cytoplasm and diseased tissue is low
• The targeting of liposomes is not good
• The stability of the constructed drug carrier is poor
• The drugs delivered are more toxic to healthy cells

Key features:

• 14:0 DAP
• 16:0 DAP
• 16:0 DGS
• 18:0 DAP
• 18:1 DAP
• 18:1 DGS
• DOBAQ
• N-palmitoyl homocysteine (PHC)

Key benefits:

• Increase efficacy and therapeutic index of the entrapped drug
• Low immunogenicity
• Tumor sites are better targeted by peptide modification
• Low cytotoxicity
• Easy to prepare
• Accommodate larger target genes
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• As a carrier of antitumor drugs
• As vectors for genes and oligonucleotides
• Improve the efficacy of less active drugs (as vectors for anti-parasitic drugs)
• Improve drug release ability in targeted organs and tissues
• Encapsulate and deliver hydrophilic and lipophilic drugs