PI, PIP & LPI

CD Bioparticles, a renowned company in the global market, is committed to revolutionizing biotechnology to improve human health. We offer an array of top-notch PI & LPI products that are pivotal for drug carrier development and physiological function research.

Phosphoinositides (PI) are minor components of cellular membranes found in eukaryotes. These molecules are similar to other phospholipids, but their head group is a cyclic myo-inositol. This inositol head group possesses free hydroxyl groups at positions D2-D6 and is readily phosphorylated by lipid kinases at hydroxyl groups D3, D4, and D5. The seven different combinatorially phosphorylated forms (PIPns) of the inositol head group contain valuable information content. PI molecules function as acidic addresses that identify different membranes, and they instruct proteins on how to behave in those membranes. These phosphorylated inositol groups can be found in various locations, including the endoplasmic reticulum, early and late endosomes, trans-Golgi, secretory granules, and the plasma membrane.

Lysophosphatidylinositol (LPI) is believed to play a significant role in several diseases. It affects multiple cell functions such as cell growth, differentiation, and mobility in cell types like cancer cells, endothelial cells, and nerve cells. G-protein coupled receptor 55 (GPR55) is thought to be a potential LPI receptor. Evidence suggests that LPI plays a vital role in metabolic functions and possibly metabolic diseases.

CD Bioparticles takes pride in providing a range of phospholipid products that are vital for biological research and drug carrier development.