Sphingolipids

Sphingolipids are generally thought to protect the cell surface from harmful environmental factors by forming the mechanically stable and chemically resistant outer lobules of the plasma membrane lipid bilayer. Certain complex sphingolipids have been found to be involved in specific functions such as cell recognition and signaling. CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Acid hydrolytic drugs have poor stability and retention properties
• The stability of the constructed drug carrier is poor
• The toxicity of the drug being delivered is higher
• The compatibility between the drug carrier and the host cell is poor
• The sphingolipids ratio of the drug loading formula is not ideal
• The absorption and release of drugs are blocked
• The side effects and bitter taste of drugs are hard to accept
• Sensitive active agents are easily degraded in vivo

Key features:

• Ceramides  N-acylated sphingoid bases lacking additional head groups
• Sphingosines  18-carbon amino alcohol with an unsaturated hydrocarbon chain
• Sphingomyelin  consist of phosphocholine and ceramide, or a phosphoethanolamine head group
• Glycosphingolipids  sphingolipids with an attached carbohydrate
• Phosphosphingolipids 
• Sphingolipid Metabolism  intermediate metabolite of sphingolipids
• Phytosphingosine & Derivatives  

Key benefits:

• Increase efficacy and therapeutic index of the entrapped drug
• Flexible routes of administration (subcutaneous, intravenous, intramuscular, oral and percutaneous)
• The structure is flexible and can be coupled with site-specific ligand to achieve active targeting
• Improved stability over other drug solubility vehicles
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• Regulate cell growth, differentiation, senescence, necrosis, proliferation and apoptosis
• Improve the stability of acid hydrolytic drugs
• Provide selective passive targeting to tumor tissue in cancer patients
• Improve drug release ability in targeted organs and tissues
• Regulate a variety of signaling pathways and treat inflammation
• Research on atherosclerosis, angiogenesis, insulin resistance, stem cells, etc
• Study on lipid metabolism and the pathway of regulating inflammation