Drug Loaded Liposomes

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • Limited preformulated drug-loaded liposomes for your in vitro and in vivo studies
  • Complicated formulation of the drug-loaded liposomes with optimized loading yield of different drug molecules
  • Limited options for tracking and detection of cell uptake (e.g. macrophage) experiments
  • Fast clearance of the drug-loaded liposomes for in vivo studies
  • Low cell specific targeting or tissue specific targeting of the drug-loaded liposomes
  • Tedious drug-loaded liposome formulation, purifications, and production

Drug Loaded Liposomes Key features:

  • Liposomal ATP
    • PEGylated Liposomal ATP
      • Negatively Charged
      • Neutral Charged
      • Positively Charged
    • Non- PEGylated Liposomal ATP
      • Negatively Charged
      • Neutral Charged
      • Positively Charged
    • Fluorescent Liposomal ATP
    • Liposomal encapsulated ATP preventing cell death and tissue dysfunction
  • Liposomal DOTA
    • DOTA encapsulated liposomes are used for remote loading of radioactive divalent ions such as radioactive copper into the liposomes.
  • Liposomal Topotecan
  • Liposomal Paxlitaxel
  • Liposomal Irinotecan
  • Liposomal Clodronate
    • Control of Clodronate Encapsulated Liposomes
    • Neutral Liposomal Clodronate
    • Anionic Liposomal Clodronate
    • Fluorescent Liposomal Clodronate, covering the entire spectrum
    • The Liposomal Clodronate targets the macrophage cells, then releases clodronate into the cytosol, resulting in cell death, as well as the macrophage depletion
  • Liposomal Doxorubicin
    • Non-surface Reactive Liposomal Doxorubicin
      • PEGylated Non-Surface Reactive Liposomal Doxorubicin
      • Non-PEGylated Non-Surface Reactive Liposomal Doxorubicin
      • Non-PEGylated Liposomal Doxorubicin for Post-insertion of PEG lipid Conjugated Ligands
    • Surface Reactive Liposomal Doxorubicin
      • Amine Reactive
      • Biotinylated
      • Carboxylic Acid Reactive
      • DBCO or Azide Reactive
      • Folate Reactive
      • Sulfhydryl Reactive
  • Liposomal Alendronate
    • Control of Alendronate Encapsulated Liposomes
    • Neutral Liposomal Alendronate
    • Anionic Liposomal Alendronate
    • The liposomal encapsulation efficiency of alendronate is no less than 90%
    • Liposomal alendronate depletes monocytes and macrophages efficiently
  • Liposomes for Drug Loading
    • Ammonium Gradient Liposomes for Active Loading
    • Liposomes for Loading Hydrophobic Drugs
    • Those pre-formed liposome products are created for post loading of drug molecules

Drug Loaded Liposomes Key benefits:

  • Wide coverage of pre-formulated drug-loaded liposomes
  • Maximum drug/lipid ratio at which no or minimal drug crystals seen
  • The final formulation could be sterile filtered for long term storage
  • Surface active liposomes allowing the modification of the drug-loaded liposomes to achieve cell-targeting or tissue-targeting
  • Post-drug-loading liposomes allowing customized drug loading
  • Fluorescent drug-loaded liposomes allowing tracking the drug-delivery/cell-uptake process
  • Enhanced aqueous solubility of water insoluble compounds
  • Improved stability over other drug solubility vehicles
  • Potential prolonged in vivo systemic circulation (slow release)
  • Suitable for in vitro and in vivo experiments
  • Ready-to-use

Drug Loaded Liposomes Application candidates:

  • Drug models of in vitro or in vivo studies of the chemotherapy
  • Macrophage depletion to achieve immune deficient animal models
  • Tracking and detection of cell uptake (e.g. macrophage)
  • Long circulation applications
  • Cell-targeting or tissue targeting drug delivery
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