CD Bioparticles’ products with deep understanding of the strategies and the applications of various of delivery cargos with precise designs and advanced technical platforms can help you to solve:
The challenges you might meet:
- Limited options for tracking and detection of fusion, pore forming, and cell uptake (e.g. macrophage) experiments
- Hard to track and image the distribution of the liposomes
- Limited wavelength coverage for your tracking and detection experiments
- Issue of quenching or fluorescence compensation
- Non-active fluorescent liposomes which cannot be conjugated with other molecules
- Tedious chemical synthesis, formulation, and purifications
Fluorescent Liposomes Key Features
- Fluorescent Plain Liposomes
- Fluorescent control formulations for many different types of liposome formulations
- Fluorescent Reactive Liposomes
- Surface reactive fluorescent liposomes for conjugation of active biomolecules, useful for tracking and targeting simultaneously
- Amine reactive fluorescent liposomes
- Biotinylated fluorescent liposomes
- Carboxylic acid reactive fluorescent liposomes
- DBCO or Azide reactive fluorescent liposomes (Click chemistry)
- Folate fluorescent liposomes
- Sulfhydryl reactive fluorescent liposomes
- Fluorescent Drug Loaded Liposomes
- Clodronate encapsulated fluorescent liposomes
- ATP encapsulated fluorescent liposomes, Lyophilized
- Doxorubicin encapsulated fluorescent/plain liposomes
- PEGylated fluorescent liposomes
- Fluorescent Liposomes for DNA/RNA Delivery
- DOTAP based
- DDAB based
- DOTMA based
- DC-Cholesterol based
- GL-67 based
- Fluorescent options:
- DiA (ex/em: 456/590 nm), DiD (ex/em: 644/665 nm), DiI (ex/em: 549/565 nm), DiO (ex/em 484/501 nm), DiR (ex/em: 750/780 nm), NBD headgroup tagged lipid (ex/em: 460/535 nm), NBD fatty acid tail tagged lipid (ex/em: 460/534), rhodamine headgroup tagged lipid (ex/em: 560/583 nm) , dansyl headgroup tagged lipid (ex/em: 336/513 nm) and pyrene headgroup tagged lipid (ex/em: 351/379 nm)
- Remote radioactive divalent cations loadable DOTA liposomes
Fluorescent Liposomes Key benefits:
- Wide coverage of fluorescent lipophilic tracer for tracking and detection of the liposomes
- Different net charges of the fluorophores for parallel studies
- Multi-functional-group lipid useful for further conjugation and crosslinking
- Drug-loaded or non-loading fluorescent liposomes for positive control and negative control of your drug delivery tests
- Available post-insertion of the PEGylation to improve the circulation of the liposomes
- Precise control of the fluorophore substitution, well-control of the intensity-concentration dependence
- Ready-to-use
Fluorescent Liposomes Application candidates:
- Fusion experiments of two separate membranes.
- Co-encapsulating NBD/Rhodamine
- Encapsulating self-quenching octadecyl Rhodamine B
- Experiments that involve pore formation and disruption of the membrane, to study pore formation or disruption by external factors such as detergents, peptides, etc.
- Containing various sizes of dextran-FITC dye
- Tracking and detection of cell uptake (e.g. macrophage)
- Mannosylated fluorescent controls
- Standard fluorescent controls: single fluorescence or multi-fluorescence
- Conjugation with biomolecules for tracking and detecting the biomolecules
- PK/PD analysis