Ionic liquids (ILs) are liquid mixtures formed by organic cations and inorganic or organic anions under certain conditions, usually with a melting point below 100°C. The preparation process of ILs is simple and has the characteristics of low volatility, high stability, high electrical conductivity, and non-flammability. These characteristics are highly in line with the pharmaceutical concept of "green chemistry". As a "green" solvent, ILs have been widely used in the fields of synthetic catalysis, biomass conversion, electrochemistry, and liquid crystal development. At the same time, ILs also have "adjustability", that is, the physical, chemical properties and biological activities of ILs can be changed by selecting different anions and cations or different ratios of anions and cations. These two characteristics also make ILs have natural advantages in the application of medicine. In drug synthesis, ILs can replace volatile organic solvents to extract active pharmaceutical ingredients (APIs) from natural products. In pharmaceutical analysis, ILs can act as mobile phases in different chromatographic systems, forming polar gradients by adjusting the polarities of constituent ions. In drug delivery, ILs have the functions of increasing drug solubility, improving drug stability, and promoting drug permeability. In addition, ILs can also be used as drug active ingredients to constitute a new drug delivery system of API-ILs, which can be used to solve problems with low solubility, low bioavailability and polymorphism of traditional drugs.
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CAS No.: 1386375-24-1