In-Vivo Delivery

In vivo delivery is usually a fast, simple, and highly effective method that transfers in vivo target cells/tissues with small RNAs (siRNA, miRNA). It combines magnetic nanoparticles with small RNAs that remain at the magnetic target site after injection. This targeted delivery approach minimizes systemic distribution, increases targeted gene inactivation, and reduces toxicity. In addition, magnetic forces enhance the absorption of magnetic nanoparticles by the target tissue, thus increasing the efficiency of noise cancellation. This makes the required delivery process shorter, which is crucial for improving delivery of small RNAs in the body. In-vivo delivery products are designed to meet in-vivo quality.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Nucleic acid drugs have poor ability to penetrate cell membranes
• Drugs in vivo do not have the ability to target
• Chemotherapy drugs have poor specificity and systemic toxicity
• Some anticancer drugs have poor hydrophilicity and are prone to multidrug resistance
• The bioavailability of siRNA in the cytoplasm is low

In-Vivo Delivery Key features:

• Small Animals Transfection Reagents
• Nanoparticles Formulation for Silencing
• Nanoparticles Formulation for Viral Vectors
• Magnetic Nanoparticles Formulation Based on Polymers
• Magnetic Nanoparticles Formulation Based on Cationic Lipid

In-Vivo Delivery Key benefits:

• Improve the bioavailability of drugs and reduce toxicity
• Increase the sensitivity of tumor cells to chemotherapy drugs
• Simultaneous delivery of a variety of drugs with different solubility
• Long cycle half-life, sustainable drug delivery
• The process is simple and requires no additional optimization steps
• Low toxicity, safe operation
• Ready-to-use

In-Vivo Delivery Application candidates:

• To achieve the silencing effect of tumor-related specific genes
• Antisense therapy
• Cancer surveillance, diagnosis and treatment
• Treat a wide range of genetic disorders
• Gene editing to treat all kinds of diseases