Liposomes for DNA/RNA Delivery

CD Bioparticles’ products with deep understanding of the strategies and the applications of various of delivery cargos with precise designs and advanced technical platforms can help you to solve:

The challenges you might meet:

  • Limited liposome stability and the low circulation times in the blood
  • Not-optimized PEGylation limiting the transfection efficiency
  • Tedious chemical synthesis, formulation, and purifications

DNA/RNA Delivery Liposomes Key Features

  • DDAB Liposomes for DNA/RNA Delivery
    • Non-cholesterol-based cationic lipids for gene delivery
    • pH-sensitive liposomes
    • The accumulation and degradation do not occur
  • GL-67 Liposomes for DNA/RNA Delivery
    • Cholesterol-based design such as DC-Cholesterol and GL-67 lipids
    • GL-67 is a cationic analogue of cholesterol. GL-67 by itself doesn't form liposomes and it should be added to a matrix lipid
  • DOTMA Liposomes for DNA/RNA Delivery
    • DOTMA is an analogue of DOTAP in which there is an ether bond between fatty acid and propyl backbone instead of an ester bond in DOTAP. The ether bond prevents the hydrolysis of the lipid
  • DOTAP Liposomes for DNA/RNA Delivery
    • DOTAP based liposomes containing DOPE are mostly suitable for in vitro studies and DOTAP based liposomes containing cholesterol are mostly suitable for in vivo studies
    • Mixing DOTAP with DNA results in spontaneously formed stable complexes that can be directly added to cell culture medium. These complexes fuse with the cell membrane and release DNA into the cytoplasm
    • Use approximately 5-10 μg DOTAP per μg DNA and approximately 10-20 μg DOTAP per mL cell culture medium
  • DODAP Liposomes for DNA/RNA Delivery:
    • Suitable for in the formulation of stable nucleic acid lipid vesicles and in the preparation and physicochemical characterization of antisense oligodeoxyribonucleotide (ODN)-containing folate (FA)-targeted or non-targeted liposomes

DNA/RNA Delivery Liposomes Key benefits:

  • Various of cationic liposomes useful for gene delivery
  • The accumulation and degradation do not occur for those pH-sensitive liposomes
  • The cholesterol-based cationic lipid used as the major hydrophobic domain of liposomes for gene delivery due to being less toxic than other cationic lipids
  • Optimized liposome composition improving transfection efficiency and stability
  • Fluorescent cationic liposome useful tracking and imaging of the transfection
  • Post PEGylation useful for optimizing the PEG ratio

DNA/RNA Delivery Liposomes Application candidates:

  • DNA/RNA delivery
  • Negative-charge drug molecule delivery
  • Tracking and imaging of the transfection
  • Long circulation applications
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