Living Cell-Based Drug Delivery Systems


Various living cell-based drug delivery systems products can be prepared and characterized by CD Bioparticles. Relying on professional expertise, research team and equipments, we can provide you with cell-based delivery products and services with high targeting, high purity, high coating rate and site-specific expression to improve drug accumulation and treatment efficiency on targeted tissues or cells, and to reduce systemic toxicity.

Introduction to Living Cell-Based Drug Delivery Systems

Cells have the natural ability to perceive, integrate, and respond to the dynamic environment in the body. Living cells can be used as carriers of therapeutic drugs. Drugs are encapsulated in cells or attached to the cell surface (Figure 1), and then transported to the lesion site through body fluids. Inner encapsulation of cells can improve the pharmacokinetic characteristics of drugs, or significantly increase the targeting of drugs to pathological conditions. Cellular drug carriers such as immune cells, anucleated cells (red blood cells and platelets), stem cells, and bacteria have become research targets.

Methods of Drug Loading

Figure 1 Methods of Drug Loading[1]

The Specific Features of Living Cell-Based DDS include[2]:

  • Immune cells (Macrophages, neutrophils and T cells): Excellent biocompatibility, have little interaction with normal cells, and can be active at specific cells and sites.
  • Anucleated cells (red blood cells and platelets): No nucleus and genetic material, and no inherent risk of abnormal growth or cancer. Can circulate unhindered in the blood for several days, with a high surface-to-volume ratio for oxygen supply and greater flexibility when traversing the circulatory system.
  • Stem cells: Have the potential to generate different types of cells, can tolerate cancer tissues; have regenerative, immunomodulatory, and anti-inflammatory properties; are biodegradable and biocompatible, able to target specific cells based on chemotactic signals and infiltrate specific tumor types.
  • Bacteria: Inhabit niches in specific parts of the body, can target specific sites in the body; survive in the tumor microenvironment, and continue to proliferate in tumors due to immunosuppression and unique biochemistry.

The applications of living cell-based DDS include:

  • Improve the targeting;
  • Improve the precise releasing;
  • Improve the permibility;
  • Improve the biocompatibility;
  • Reduce the uncontrollable degradation and improve stability.

Our Living Cell Drug Delivery Featured Services

  • Design of cell-dependent drug carriers: Design and produce the most suitable drug-cell combination scheme according to your drug characteristics, tumor microenvironment, and experimental purposes with different methods, including, but not limited to, Figure 1.
  • Cell processing: Isolate of cells, drug encapsulation, drug attachment, membrane extraction, increase drug loading, etc.
  • Bioparticles characterization: Including, but not limited to, bioparticle component analysis, size and morphology analysis.
  • Analysis in vitro and in vivo: Drug activity analysis, cell viability assay, cellular uptake analysis, intracellular distribution analysis, localization analysis, homing ability analysis, etc.

Contact us to learn more about our cell-based drug delivery systems.

Quotations and Ordering

Quotations and Ordering

References:
1. Wu Y, Liu Y, Wang T, Jiang Q, Xu F, Liu Z: Living cell for drug delivery. Engineered Regeneration 2022, 3(2):131-148.
2. ZHANG Meng, Rongqin H: Research Progress of Drug Delivery Systems Based on Living Cells and Their Derivatives. MATERIALS CHINA 2022, 41:697-704.

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