mRNA Transfection

mRNA transfection is a process in which mRNA is introduced into cells and expressed. The mRNA transcribed or synthesized in vitro is taken directly into the cell. Since it can be translated directly without transcription, the results obtained by mRNA transfection are faster and more direct than those obtained by DNA transfection. Of course, it is limited to instantaneous expressions. Unlike DNA and viral vectors, mRNA will not be inserted into the genome to affect genetic information, and the protein encoded by mRNA will only be expressed instantaneously and then degraded quickly, so there is no risk of gene integration and it is highly safe. Compared with proteins and viruses, mRNA is able to quickly translate the required proteins within cells and has a faster effect. And simple production, low cost, easy industrial production.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • Electrostatic repulsion makes it harder for mRNA molecules to cross cell membranes
  • mRNA is single stranded, unstable and easily degraded by multiple enzymes
  • mRNA synthesized in vitro is inefficient for use in vivo
  • mRNA is not a stable macromolecule and is sensitive to shear stress
  • The half-life of mRNA in vivo is short, and sufficient protein expression cannot be obtained
  • Nonspecific biological distribution of exposed nucleic acids
  • No safe and effective carrier of nucleic acid is found

mRNA Transfection Key features:

mRNA Transfection Key benefits:

  • Low immune rejection
  • Good biocompatibility
  • mRNA does not integrate into the genome and has high transfection efficiency
  • Low toxicity, safe operation
  • Large-scale production can be achieved
  • Surface active liposomes allowing the modification of the mRNA-loaded liposomes to achieve cell-targeting or tissue-targeting
  • Suitable for in vivo experiments
  • Ready-to-use

mRNA Transfection Application candidates:

  • Immunization and therapy of mRNA vaccines in malignant tumors
  • mRNA vaccines protect against infectious diseases such as influenza, rabies, HIV and Zika virus infections
  • Protein replacement therapy
  • Regulates cell fate and differentiation, repair damaged tissue
  • Gene editing using mRNA recombination technology
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