CD Bioparticles is a leading manufacturer and supplier of various drug delivery products, including nanocages for R&D and commercialization in a variety of application areas. Nanocages have played a vital role in the development and implementation of many useful tools for researches involving biology, chemistry and material sciences as well as nanomedicine.
Introduction to Nanocages
Nanocages refer to hollow nanostructures with porous walls, they have attracted greater attention as a new class of drug-carriers, as a result of their possibilities in multi-modality medical treatments and theranostics. Their excellent intrinsic properties, including porous structure, high loading capacity, smart release, surface tailorability, multi-functionality and low likelihood of unfavorable immune responses, have make nanocages one of the most attractive strategies to improve the delivery of therapeutic molecules.
Generally, nanocages can be divided into two groups as follows:
Table 1. Groups of nanocages and their advantages in summary.
Virus-like particles (VLPs)
|They show mild interaction with living cells, especially protein nanocages constructed from endogenous proteins. Protein nanocages are often not recognized as foreign. And they can be biologically or chemically engineered or modified using different approaches.|
Hybrid metal-organic nanocages
Above all, it is worth noted that protein nanocages are commonly used because of their construction from endogenous proteins such as ferritin, heat shock proteins, encapsulins, vault proteins. They perform biological roles in living cells, such as iron homeostasis by storage of excess iron in its core, catalysis of products in glucose metabolism, protective roles for DNA from oxidative damage and more. Many advantages of nanocages suggest their potential applications in multimodal treatments, multi-responsive release systems and theranostic applications.
Figure 1. Schematic illustration of various nanocaged platforms, their ability to target cells and intracellular delivery via receptor-mediated uptake. (Zangabad, P. S., et al. Nanoscale, 2017, 9(4), 1356-1392.)
Our Featured Services
CD Bioparticles is specialized in the development of drug delivery systems and customizing nanoparticles for drug delivery utilizing our core technologies. With our high-quality products and services, the efficacy of your drug delivery can be tremendously improved.
We offer well-designed drug-loaded nanocage products as virus-like particles (VLPs), protein nanocages, DNA nanocages, supramolecular nanosystems, hybrid metal–organic nanocages, gold nanocages, carbon-based nanocages and silica nanocages. Clients may select the material type, particle size, size distribution, and/or surface functional groups such as carboxyl or amine groups. And we also provide custom services for designing and synthesizing nanocages with special required drugs loading, together with its analysis and characterization before and after drug encapsulation.
Quotations and Ordering
1. Zangabad, P. S., et al. Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger. Nanoscale, 2017, 9(4), 1356-1392.
2. Schoonen, L., van Hest, J. C. Functionalization of protein-based nanocages for drug delivery applications. Nanoscale, 2014, 6(13), 7124-7141.
3. Lee, E. J., Lee, N. K., Kim, I. S. Bioengineered protein-based nanocage for drug delivery. Advanced drug delivery reviews, 2016, 106, 157-171.
4. Chen, J., Saeki, F., et al. Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. Nano letters, 2005, 5(3), 473-477.