SPDP-Val-Cit-PAB-PNP


SPDP-Val-Cit-PAB-PNP

SPDP-Val-Cit-PAB-PNP

Catalog:CDAX018

Unit Size:5 mg, 10 mg

INQUIRY Datasheet

Specifications
Common Use SPDP-Val-Cit-PAB-PNP-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. The Boc group can be deprotected under acidic conditions to generate a free amine group.
Structure SPDP-Val-Cit-PAB-PNP
Molecular Weight 741.84
Purity ≥95%
Molecular Formula C33H39N7O9S2
CAS No. 159857-81-5
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