Clipos™ SP600125 Encapsulated Liposomes
Specifications
Description
|
PEGylated liposomes containing JNK inhibitor SP600125 (Nsc75890). SP600125 is a reversible, ATP-competitive broad-spectrum JNK inhibitor (JNK1/JNK2, IC50 40 nM; JNK3, IC50 90 nM). with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A, FLT3 and TRKA. SP600125 inhibits ferroptosis, autophagy, and activates apoptosis. SP600125 is insoluble in aqueous media. This product is a pre-formulated liposomal version of Sp600125 which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only. |
Lipid composition
|
PEGylated Liposomes |
Liposome Size
|
70-120 nm |
Lipid Molar Concentration
|
60 mM |
Encapsulated Drug
|
SP600125 |
Drug concentration
|
250 mcg/mL |
Inside Buffer
|
292 mM sucrose, 0.5% DPBS (1X) |
Outside Buffer
|
292 mM sucrose, 0.5% DPBS (1X) |
Storage
|
2 °C to 8 °C (do not freeze), protect from light |
Shelf-life
|
At least 1 month |
CAS No.
|
129-56-6 |
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