Clipos™ Adavosertib Encapsulated Liposomes
Specifications
Description
|
PEGylated liposomes containing Wee-1 kinase inhibitor adavosertib (MK1775; AZD1775), remote loaded by an ammonium sulfate gradient. The lipid composition of the liposomes is the same as Doxil. Sterile filtered and supplied ready for use in preclinical studies in rodents or in vitro. Adavosertib is a potent, ATP-competitive Wee-1 kinase inhibitor, which hinders the G2 DNA damage response checkpoint and is reported to enhance cytotoxic effects of several compounds including 5-FU and NSC 613327. For preclinical research use only. |
Lipid composition
|
HSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio) |
Liposome Size
|
70-120 nm |
Lipid Molar Concentration
|
27.2 mM |
Encapsulated Drug
|
Adavosertib |
Drug concentration
|
1.0 mg/mL |
Inside Buffer
|
250 mM Ammonium Sulfate, pH 5.5 |
Outside Buffer
|
Normal Saline (154 mM NaCl, pH 5.5) |
Storage
|
2 °C to 8 °C (do not freeze) |
Shelf-life
|
6 months |
CAS No.
|
955365-80-7 |
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