N-piperidine Ibrutinib hydrochloride


N-piperidine Ibrutinib hydrochloride

N-piperidine Ibrutinib hydrochloride

Catalog:CDMDC18

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Specifications
Common Use N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.
Structure N-piperidine Ibrutinib hydrochloride
Molecular Weight 422.91
Purity 0.953
Molecular Formula C22H23ClN6O
CAS No. 2231747-18-3
Appearance Solid
Storage • -20°C, sealed storage, away from moisture and light
• In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solubility • DMSO: 100 mg/mL (236.46 mM)
• H2O: 50 mg/mL (118.23 mM)
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