Common Use | Spermine phosphoramidite is used to produce oligospermine-oligonucleotide conjugates - Zip Nucleic Acids Oligos. The conjugates are believed to use the oligospermine to seek out and move along (scan) oligonucleotide strands until the probe complementary sequence is located. The oligospermine then performs the function of stabilizing the formed duplex by reducing electrostatic repulsion, thereby leading to significantly increased binding affinities. Spermine phosphoramidite is simple to use in oligonucleotide synthesis and can be added multiple times at the 3' or 5' terminus. Deprotection and isolation are also straightforward. HPLC analysis of the conjugates requires high pH to suppress the ionization of the spermine residues. |
Structure | |
Molecular Weight | 1233.17 |
Molecular Formula | C56H73F12N6O9P |
Storage | Freezer storage, -10 to -30°C, dry |
Stability | 1-2 days |
Catalog: CDGLR01
Catalog: CDGLR02
Catalog: CDGLR03
Catalog: CDGLR04
Catalog: CDGLR05
Catalog: CDGLR06
Catalog: CDGLR07
Catalog: CDGLR08