poly(DETOSU-CHDM) [1:1] (Type II)

Catalog:DCHDM1

Unit Size:5g

Specifications

Molecular Weight	5-30 kDa
Storage	Protect against moisture. Store at -20°C.
Handling	Handle with normal care, but minimize exposure to moisture to avoid degradation.
Product Description	Poly(ortho esters) (POE) belong to a class of degradable polymeric materials. Initially described in 1970 and developed specifically for drug delivery applications. Four distinct families of POE (type I-IV) have been developed, but only type II and IV are undergoing further development and commercialization. Unlike polyesters such as PLA and PLGA, which undergo bulk degradation, most poly(ortho esters) degrade through surface erosion. This is a result of hydrophobicity preventing water from dissolving or entering the bulk polymer material thereby limiting hydrolysis of the ortho ester bonds to the accessible surface layers. Poly(ortho esters) are relatively stable at alkaline or neutral conditions, but hydrolyze rapidly at acidic conditions.
Structure