7,4'-Dihydroxyflavone


7,4'-Dihydroxyflavone

7,4'-DHF

Catalog:CDPE23-019-L

Unit Size:5 mg, 10 mg, 50 mg, 100 mg

INQUIRY Datasheet

Specifications
Common Use 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM
Structure 7,4'-Dihydroxyflavone
Molecular Weight 254.24
Purity ≥99%
Molecular Formula C15H10O4
CAS No. 2196-14-7
Appearance Solid
Storage Powder: -20 °C, 3 years; 4 °C, 2 year. In solvent: -80 °C, 2 years; -20 °C, 1 year
Solubility Soluble in DMSO
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