Clipos™ Oct-4 mRNA Lipid Nanoparticles


Catalog:CDL23-021-L

Unit Size:200 μL

INQUIRY Datasheet

Specifications
Description OCT-4 (Octamer-binding transcription factor 4) is a transcription factor protein of the POU (Pit-Oct-Unc) family, encoded by the POU5F1 gene. The transcription factor Oct-4 is capable of inducing an embryonic stem cell-like state, and it works together with Sox2, Klf4, and usually c-Myc to generate induced pluripotent stem cells (iPSCs). These factors are commonly referred to as "Yamanaka reprogramming factors," and this reprogramming effect reverts human fibroblasts to iPSCs. In addition, Oct-4 plays a crucial role in determining the fate of endoplasmic cells and embryonic stem cells, with the function of maintaining the pluripotency of embryonic cells or regulating the proliferation of cancer cells. This product is designed as a tool for the delivery and expression of OCT-4 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of OCT-4 mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The OCT-4 protein is about 40 kD and consists of 360 amino acids
Lipid composition SM-102/DSPC/Cholesterol/DMG-PEG2000
Encoding mRNA POU5F1
In Vitro QC (Cell Types) HEK293S
Technology Applications Protein research
Storage Store at 4°C
Technical Notes Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ EGFP mRNA Lipid Nanoparticles CDPM01 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ mCherry mRNA Lipid Nanoparticles CDPM02 INQUIRY
Clipos™ mCherry-Luciferase mRNA Lipid Nanoparticles CDPM03 INQUIRY
Clipos™ Luciferase mRNA Lipid Nanoparticles CDPM04 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ CAS 9-RNA Lipid Nanoparticles-HA CDPM05 INQUIRY
Clipos™ ANTI-BCMA mRNA Lipid Nanoparticles CDPM06 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-CD19 mRNA Lipid Nanoparticles CDPM07 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-HER2 mRNA Lipid Nanoparticles CDPM08 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Products
Fill out the form below
to receive a quote

GET A QUOTE

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © 2024 CD Bioparticles. All rights reserved.
0
Inquiry Basket
Inquiry