Clipos™ IL-21 mRNA Lipid Nanoparticles

Catalog:CDL23-038-L

Unit Size:200 μL

INQUIRY Datasheet

Specifications
Description Interleukin 21 (IL-21), encoded by the IL21 gene, is a member of the common gamma-chain family of cytokines with immunomodulatory activity. IL-21 plays a role in innate and adaptive immune responses by inducing the differentiation, proliferation and activity of a variety of target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. IL-21 is expressed on activated human CD4+ T cells but not in most other tissues. IL21 is considered a key signal that triggers the proliferation of chronic lymphocytic leukemia cells. Dysregulation of IL-21 is associated with a variety of immune-mediated diseases, including lupus, psoriasis, and chronic inflammatory diseases. Additionally, IL-21 was found to be produced by Hodgkin's lymphoma (HL) cancer cells, suggesting that IL-21 may be a potential treatment or a possible test for HL. This product is designed as a tool for the delivery and expression of human IL21 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of hIL21 mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The IL21 protein is about 18 kD and consists of 162 amino acids
Lipid composition SM-102/DSPC/Cholesterol/DMG-PEG2000
Encoding mRNA IL-21
In Vitro QC (Cell Types) HEK293S
Technology Applications Protein research
Storage Store at 4°C
Technical Notes Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
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