Clipos™ CD70-TF tag mRNA Lipid Nanoparticles

Catalog:CDL23-041-L

Unit Size:200 μL

INQUIRY Datasheet

Specifications
Description CD70 (Cluster of Differentiation 70) is a type II transmembrane glycoprotein encoded by the CD70 gene and belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27 and a surface antigen on activated but not resting T and B lymphocytes. CD70 expression is upregulated after dendritic cell maturation. CD27 is the sole receptor for CD70, a member of the TNF receptor family that is constitutively expressed on thymocytes, naive T cells, B cells, and natural killer cells. Through binding to CD27, CD70 induces the proliferation of co-stimulatory T cells, enhances the generation of cytolytic T cells, and promotes T cell activation. This cytokine has also been reported to play a role in the regulation of B cell activation, the cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 has been shown to be overexpressed in several types of cancer, including Hodgkin's and non-Hodgkin's lymphomas, as well as certain types of solid tumors. This overexpression is associated with cancer initiation and progression, suggesting that anti-CD70 antibodies may be a possible treatment for CD70-positive lymphomas. This product is designed as a tool for the delivery and expression of TF-tagged human CD70 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of hCD70-TF mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The hCD70-TF protein is about 23 kD, consisting of hCD70 and a C-terminal TF tag (15 amino acids)
Lipid composition SM-102/DSPC/Cholesterol/DMG-PEG2000
Encoding mRNA CD70
In Vitro QC (Cell Types) HEK293S
Technology Applications Protein research
Storage Store at 4°C
Technical Notes Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ EGFP mRNA Lipid Nanoparticles CDPM01 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ mCherry mRNA Lipid Nanoparticles CDPM02 INQUIRY
Clipos™ mCherry-Luciferase mRNA Lipid Nanoparticles CDPM03 INQUIRY
Clipos™ Luciferase mRNA Lipid Nanoparticles CDPM04 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ CAS 9-RNA Lipid Nanoparticles-HA CDPM05 INQUIRY
Clipos™ ANTI-BCMA mRNA Lipid Nanoparticles CDPM06 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-CD19 mRNA Lipid Nanoparticles CDPM07 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-HER2 mRNA Lipid Nanoparticles CDPM08 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © 2024 CD Bioparticles. All rights reserved.
0
Inquiry Basket
Inquiry