Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3)

Catalog:CDL23-049-L

Unit Size:200 μL

INQUIRY Datasheet

Specifications
Description PD-L1 (programmed cell death protein ligand 1), also known as CD274, is a type 1 transmembrane protein mainly expressed on the cell surface of tumor cells or antigen-presenting cells. PD-1, (also known as CD274), is a membrane protein of the human immunoglobulin superfamily, expressed on the surface of T cells, primary B cells, and myeloid-derived dendritic cells. PD-1 and PD-L1 were also found to be co-expressed on the surface of SCLC cancer cells. PD-1/PD-L1 act as inhibitory checkpoint molecules in the immune system. PD-1 binds to PD-L1 to form a complex and transmit inhibitory signals to reduce the proliferation and activity of killer T lymphocytes. Blocking PD-1 with anti-PD-1 antibody, or blocking PD-L1 with anti-PD-L1 antibody, can inhibit the formation of PD-1/PD-L1 complex, thereby activating the immune system to attack tumors. Therefore, both anti-PD-1 and anti-PD-L1 antibodies have been used as adjuvant therapy for certain types of cancer. This product is designed as a tool for the delivery and expression of PDL-1 TF secreted mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of PDL-1 TF secreted mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. This PDL-1 TF secreted fusion protein is approximately 26 kD, consisting of the PD-1 extracellular domain (ECD) and a C-terminal TF tag (15 amino acids)
Lipid composition SM-102/DSPC/Cholesterol/DMG-PEG2000
Encoding mRNA CD274
In Vitro QC (Cell Types) HEK293S
Technology Applications Protein research
Storage Store at 4°C
Technical Notes Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
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