Clipos™ CXCL9-TF tag mRNA Lipid Nanoparticles(v2)

Catalog:CDL23-084-L

Unit Size:200 μL

INQUIRY Datasheet

Specifications
Description Chemokine CXCL9 is a small cytokine that belongs to the CXC (C-X-C motif) chemokine family. It is encoded by the CXCL9 gene and has the functions of inducing chemotaxis, promoting differentiation and proliferation of leukocytes, and causing tissue extravasation. CXCL9 regulates immune cell migration, differentiation and activation through the CXCR3 receptor. The CXCL9/CXCR3 axis affects the polarization of tumor-associated macrophages (TAMs) that exert regulatory activity in the tumor microenvironment. Studies have shown that CXCL9 and its two family members, CXCL10 and CXCL11, promote tumor suppressor lymphocyte infiltration in solid tumors through CXCR3. Furthermore, the action of CXCR3 has been shown to be critical for successful immune checkpoint inhibition in preclinical cancer models due to the recruitment and activation of T cells. The CXCL9 gene expression has identified as the most powerful marker for predicting immune checkpoint blockade response in multiple tumor types. It is very meaningful to study the relationship between the CXCL9/CXCR3 axis and the immune checkpoint inhibitor PDL-1/PD-1. It has been reported that blocking the PDL-1/PD-1 axis in T cells may trigger a positive feedback loop at the tumor site via the CXCL9/CXCR3 axis. This product is designed as a tool for the delivery and expression of CXCL9-TF mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of CXCL9-TF mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The CXCL9-TF fusion protein is approximately 15 kD, consisting of full-length CXCL9 (125 amino acids) and a C-terminal TF tag (15 amino acids)
Lipid composition SM-102/DSPC/Cholesterol/DMG-PEG2000
Encoding mRNA CXCL9
In Vitro QC (Cell Types) HEK293S
Technology Applications Protein research
Storage Store at 4°C
Technical Notes Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ EGFP mRNA Lipid Nanoparticles CDPM01 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ mCherry mRNA Lipid Nanoparticles CDPM02 INQUIRY
Clipos™ mCherry-Luciferase mRNA Lipid Nanoparticles CDPM03 INQUIRY
Clipos™ Luciferase mRNA Lipid Nanoparticles CDPM04 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ CAS 9-RNA Lipid Nanoparticles-HA CDPM05 INQUIRY
Clipos™ ANTI-BCMA mRNA Lipid Nanoparticles CDPM06 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-CD19 mRNA Lipid Nanoparticles CDPM07 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-HER2 mRNA Lipid Nanoparticles CDPM08 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © 2024 CD Bioparticles. All rights reserved.
0
Inquiry Basket
Inquiry