Clipos™ CXCR1 mRNA Lipid Nanoparticles


Catalog:CDL23-086-L

Unit Size:200 μL

INQUIRY Datasheet

Specifications
Description CXCR1 (C-X-C motif chemokine receptor 1), also known as CD181, is a member of the G protein-coupled receptor family and is encoded by the CXCR1 gene. CXCR1 is expressed on neutrophils, monocytes, macrophages, basophils, natural killer T cells, and interacts with high affinity with the primary ligand CXCL8 (interleukin 8 or IL8). By binding to IL8, CXCR1 transduces signals through a G protein-activated second messenger system, leading to neutrophil chemotaxis and activation. CXCR1 has also been shown to play an important role in the regulation of neuronal apoptosis. CXCR1 was found to be expressed on the cell surface of white blood cells and tumor cells, and this expression was independent of cancer stage. In this way, it has been identified as a potential therapeutic target. This product is designed as a tool for the delivery and expression of CXCR1 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of CXCR1 mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. CXCR1 protein is approximately 39 kD, consisting of 350 amino acids
Lipid composition SM-102/DSPC/Cholesterol/DMG-PEG2000
Encoding mRNA CXCR1
In Vitro QC (Cell Types) HEK293S
Technology Applications Protein research
Storage Store at 4°C
Technical Notes Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ EGFP mRNA Lipid Nanoparticles CDPM01 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ mCherry mRNA Lipid Nanoparticles CDPM02 INQUIRY
Clipos™ mCherry-Luciferase mRNA Lipid Nanoparticles CDPM03 INQUIRY
Clipos™ Luciferase mRNA Lipid Nanoparticles CDPM04 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ CAS 9-RNA Lipid Nanoparticles-HA CDPM05 INQUIRY
Clipos™ ANTI-BCMA mRNA Lipid Nanoparticles CDPM06 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-CD19 mRNA Lipid Nanoparticles CDPM07 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ANTI-HER2 mRNA Lipid Nanoparticles CDPM08 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Products
Fill out the form below
to receive a quote

GET A QUOTE

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © 2024 CD Bioparticles. All rights reserved.
0
Inquiry Basket
Inquiry