Common Use | Boc-protected amine and alkyne conjugated PEG-OH (Boc-amine alkyne-PEG-OH) is a trifunctional PEG derivative, which has amine and alkyne group sharing one PEG end and hydroxyl group on the other end. Multiple entities may be linked together by trifunctional PEGs. Boc-amine can be deprotected by acid (TFA) to free amine, which react with carboxylic acid and its active esters, and isocyanates. It can also react with carbonyl such as ketone and aldehyde. Alkyne were used to react azide group “click” chemistry in mild condition, which is very useful for bioconjugation. OH can be further derivatized for bioconjugation. |
Structure | |
PEG Molecular Weight | 3,400 Da |
Functional Group | Boc-protected amine/Hydroxyl/Alkyne |
Q: How do I deprotect the BOC reagents?
A: Standard BOC Amino Acid Deprotection
• 50% (v/v) TFA/DCM; 50 minutes at room temperature
• Follow with washings with 5% (v/v) DIPEA/DCM to remove TFA
Catalog: CDN1382
Catalog: CDN1383
Catalog: CDN1384
Catalog: CDN1385
Catalog: CDN1386
Catalog: CDN1387
Catalog: CDN1388
Catalog: CDN1389