Fmoc Amine Azide-Poly(ethylene glycol)-COOH

Fmoc Amine Azide-PEG-COOH

Catalog:CDN1422

Unit Size:100 mg, 1 g

Specifications

Common Use	Fmoc protected amine and azide conjugated PEG-carboxylic acid (Fmoc amine azide-PEG-COOH, azide Fmoc amine-PEG-COOH) is a trifunctional PEG derivative, which has Fmoc-protected amine and azidde group sharing one end and -COOH group on the other end.Fmoc protected amine can be deprotected by piperidine to free amine which can react with carboxylic acid and its active esters, and isocyanates. It can also react with carbonyl such as ketone and aldehyde.Azide were used to react azide group “click” chemistry in mild condition, which is very useful for bioconjugation.COOH can react with amine or OH containing entities.
Structure
PEG Molecular Weight	3,400 Da
Functional Group	Fmoc-protected amine/COOH/Azide

Q & A

Q: How do I deprotect the Fmoc reagents?

A: Standard Fmoc Amino Acid Deprotection
• Place the Fmoc protected product in a round bottom flask and add 20% (v/v) piperdine in DMF (approximately 10ml/gm resin);
• Shake the mixture at room temperature for 30 minutes;
• Filter the Fmoc protected product and wash it with several portions of DMF

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