Clipos™ Doxorubicin Encapsulated Liposomes, PDP lipids, PEGylated

Catalog:CDEIMD-1003

Unit Size:2 mL, 5 mL

INQUIRY Datasheet

Specifications
Description The liposomes containing pyridyldithiopropionate (PDP) lipids are used to conjugate proteins, antibodies and other molecules containing the reactive moiety. PDP lipids are not as widely used as maleimide lipids, but they do have their own niche application. The PDP group contains disulfide, which can react with sulfhydryl or thiolated proteins/antibodies. Therefore, PDP-functionalized liposomes can be used in two ways: 1) maleimide-modified antibody to a PDP-modified PEGylated doxorubicin liposome; 2) thiol-modified antibody to a PDP-modified PEGylated doxorubicin liposome.
Lipid composition Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-PDP (57/38/4 molar ratio)
Liposome Size 100 nm
Lipid Mass Concentration 15.93 mg/mL
Lipid Molar Concentration 21.58 mM
Functional Group PDP
Encapsulated Drug Doxorubicin
Drug concentration 2 mg/mL (3.45 mM)
Appearance The product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
Inside Buffer Ammonium Sulfate, pH 7.4
Outside Buffer Phosphate Buffered Saline, pH 7.4
Storage Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
Shelf-life 4 months.
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