Clipos™ Phosphatidylserine (PS) Liposomes


Catalog:CDECPS-1681

Unit Size:5 mL

INQUIRY Datasheet

Specifications
Description Liposomes are extensively used to study the interaction of proteins, peptides and other molecules with the surface of a lipid membrane. One of the parameters that affects this interaction is the charge of the liposomal membrane. Phosphatidylserine (PS) is a negatively charged molecule. The amount of the negative zeta potential in the liposomes depends on the molar percentage of the phosphatidylserine (PS) in the formulation. Anionic Phosphatidylserine (PS) catalog contains the products made from 0.5 up to 100 percent DOPS with various amount of negative zeta potentials. The matrix lipid DOPC that is used in the formulations does not significantly contribute to the charge of the liposomes. Anionic liposomes are used in blood complement studies and various types of in vitro studies. The structure of DOPS molecule with an anionic headgroup.
Lipid composition DOPS/DOPC (1/99 molar ratio)
Liposome Size 100 nm
Lipid Molar Concentration 10 mM
Surface Charge Anionic
Appearance White translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
Buffer Phosphate Buffered Saline, pH 7.4
Storage Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, that the size of the liposomes will also change upon freezing and thawing.
Shelf-life 4 months.
Technical Notes Liposomes are unilamellar and sized to 100 nm. If you need them to be made in another size then you should mention that at the time of ordering. Unilamellar liposomes can be made in 50 nm and 200 nm sizes. Liposomes that are larger than 200 nm are multilamellar structure.
Liposomes are made in PBS buffer at pH 7.4 but it can be made in any other buffer of your choice. You can specify your buffer at the time of ordering.
Liposomes are made in degassed buffer that is purged with argon to avoid oxidation of the unsaturated phospholipids.
Liposomes are made under sterile condition.
Liposomes are unilamellar and therefore due to their small size they will not settle in the bottom of the vial.
If you need to take multiple aliquots out of the vial during a period of time, then it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product.
Liposomes should never be frozen. Crystal ice that is formed during freezing will rupture the lipid membrane of the liposomes and change the size the liposomes particles.
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Clipos™ Phosphatidylserine (PS) Liposomes CDECPS-1669 100% DOPS 100 nm INQUIRY
Clipos™ Natural Phosphatidylserine (PS) Lipid Liposomes CDECPS-1604 100% Soy PS 100 nm INQUIRY
Clipos™ Natural Phosphatidylserine (PS) Lipid Liposomes, Lyophilized CDELPS-1248 100% Soy PS 100 nm (after hydration) INQUIRY
Clipos™ Natural Phosphatidylserine (PS) Lipid Liposomes CDECPS-1605 Brain PS/Cholesterol (70/30 molar ratio) 100 nm INQUIRY
Clipos™ Natural Phosphatidylserine (PS) Lipid Liposomes, Lyophilized CDELPS-1249 Brain PS/Cholesterol (70/30 molar ratio) 100 nm (after hydration) INQUIRY
Clipos™ Anionic Phosphatidylserine (PS) Liposomes, PEGylated CDECPSG-1588 DOPC/Cholesterol/DOPS/DOPE-PEG(2000) (60/30/5/5 molar ratio) 100 nm INQUIRY
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