Clipos™ Doxorubicin Encapsulated Liposomes, PEGylated

Catalog:CDEDOX-1014

Unit Size:2 mL, 5 mL

INQUIRY Datasheet

Specifications
Description This formulation of doxorubicin liposomes is PEGylated. The formulation is for research purposes only and for the injection to laboratory animals. Doxorubicin drug is already loaded into the liposomes using remote loading by ammonium sulfate gradient. The formulation is ready for injection.
Lipid composition HSPC/Cholesterol/DSPE-PEG(2000) (57/38/5 molar ratio)
Liposome Size 80-100 nm
Lipid Mass Concentration 15.96 mg/mL
Lipid Molar Concentration 21.62 mM
Functional Group Plain
Encapsulated Drug Doxorubicin
Drug concentration 2 mg/mL (3.45 mM)
Appearance The product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
Inside Buffer Ammonium Sulfate, pH 6.5
Outside Buffer Histidine/Sucrose Buffer, pH 6.5
Storage Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
Shelf-life 4 months.
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