Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated
Specifications
Description
|
Proteins can be covalently coupled to the liposomes via amine-reactive cyanur-groups, either directly to the vesicle surface using cyanuric chloride-activated DSPE (cyanur-DSPE) or to the distal ends of PEG-spacers using activated cyanur-PEG-PE (ammonium salt). Cyanuric chloride at the PEG terminus functions to link peptides, antibodies and other amine-containing biomolecules or nanoparticles via a nucleophilic substitution reaction under basic conditions. Antibodies or other proteins can be conjugated without any previous derivatization. |
Lipid composition
|
HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Cyanur (57/38/4/1 molar ratio) |
Liposome Size
|
100 nm |
Lipid Mass Concentration
|
15.92 mg/mL |
Lipid Molar Concentration
|
21.58 mM |
Functional Group
|
Cyanur |
Encapsulated Drug
|
Doxorubicin |
Drug concentration
|
2 mg/mL (3.45 mM) |
Appearance
|
The product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial. |
Buffer
|
Borate Buffer, pH 8.8 |
Storage
|
Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing. |
Shelf-life
|
4 months. |
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