Clipos™ Doxorubicin Encapsulated Liposomes, Folate lipids, PEGylated

Catalog:CDEIMD-1005

Unit Size:2 mL, 5 mL

INQUIRY Datasheet

Specifications
Description Folate binding protein (FBP) is an endogenous protein, which shows a very high affinity for folate. An antibody can be tagged by FBP and an immunoliposome can be formed by non-covalent and high affinity interaction between FBP and folate lipid on the surface of the liposomes. In this method, the antibody, which has been already covalently linked to FBP through a thioether linkage, is conjugated with folate-derivative liposomes. Having a relatively low molecular weight (MW 40 kDa) and a single binding site prevents liposomes from crosslinking.
Lipid composition HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Folate (57/38/4.5/0.5 molar ratio)
Liposome Size 100 nm
Lipid Mass Concentration 15.86 mg/mL
Lipid Molar Concentration 21.55 mM
Functional Group Folate
Encapsulated Drug Doxorubicin
Drug concentration 2 mg/mL (3.45 mM)
Appearance The product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
Inside Buffer Ammonium Sulfate, pH 7.4
Outside Buffer Phosphate Buffered Saline, pH 7.4
Storage Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
Shelf-life 4 months.
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