CliposTM Topotecan Encapsulated Liposomes, PEGylated

Description	Topotecan HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) with ammonium sulfate gradient by the active loading approach. The liposomes are produced by the extrusion method. The product is of high quality with Narrow particle size distribution and high drug encapsualtion efficiency.
Lipid composition	HSPC/Cholesterol/mPEG2000-DSPE (50/45/5 molar ratio)
Liposome Size	100 nm (80-110 nm)
Lipid Molar Concentration	20.0 mM
Encapsulated Drug	Topotecan HCl
Drug concentration	2.0 mg/mL
Encapsulation efficiency	> 95%
Loading Battery	250 mM ammonium sulfate
Outside Buffer	10% sucrose, 20 Mm HEPES, pH 7.0
Storage	2-8 °C
Shelf-life	3 months

Clipos™ Topotecan Encapsulated Liposomes, PEGylated