PC Cleavable Linkers


PC Cleavable Linkers include a variety of products, most of which are biodegradable ADC linkers that can be used to synthesize antibody-conjugated drugs or catalyze a variety of click chemical reactions. PC Cleavable Linkers must meet a variety of challenging constraints, such as mild cracking conditions, the use of biological orthogonal reagents, high yields at low concentrations, and the ease of eliminating excess reagents and by-products.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • The efficacy and safety of the drug delivery system are inadequate
  • The linker is unstable in blood circulation and has more side effects
  • The degradation rate of linkers is too slow, and the accumulation leads to toxicity in vivo
  • Complex PC cleavable linkers are difficult to synthesize
  • Cleavable linkers cannot break under mild conditions
  • It is difficult to remove excess reagents and by-products

Key features:

Key benefits:

  • Enhance the solubility of labeled molecules in aqueous medium
  • The structure does not affect the activity of other proteases
  • Rapid and complete rupture under mild conditions
  • Biodegradable, does not accumulate in the body toxic
  • Interact with or to manipulate the biological target
  • Suitable for in vitro and in vivo experiments
  • Ready-to-use

Application candidates:

  • Synthetic antibody-conjugated drugs
  • DNA sequencing
  • Be reactive groups for protein crosslinking, ligation or for click chemistry
  • Fluorescent probes for diagnostic tools, proteomic analysis or cell imaging
  • Tags for MS analysis or purification
  • Targeting molecules for functional proteomics or activity based probe profiling (ABPP)

PC Alkyne-PEG4-NHS carbonate ester

Catalog: CDAX036

MW: 653.64

PC Azido-PEG11-NHS carbonate ester

Catalog: CDAX035

MW: 993.03

PC Biotin-PEG3-alkyne

Catalog: CDAX034

MW: 780.89

PC Biotin-PEG3-azide

Catalog: CDAX033

MW: 825.94

PC Biotin-PEG3-NHS carbonate ester

Catalog: CDAX032

MW: 840.9

PC DBCO-PEG3-biotin

Catalog: CDAX031

MW: 1002.15

PC Mal-NHS carbonate ester

Catalog: CDAX030

MW: 562.49

PC SPDP-NHS carbonate ester

Catalog: CDAX028

MW: 608.64

PC-Biotin-PEG4-NHS carbonate

Catalog: CDAX027

MW: 810.87

PC-Biotin-PEG4-PEG3-azide

Catalog: CDAX026

MW: 914.04

PC-Biotin-PEG4-PEG4-alkyne

Catalog: CDAX025

MW: 927.08

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