PC Cleavable Linkers

PC Cleavable Linkers include a variety of products, most of which are biodegradable ADC linkers that can be used to synthesize antibody-conjugated drugs or catalyze a variety of click chemical reactions. PC Cleavable Linkers must meet a variety of challenging constraints, such as mild cracking conditions, the use of biological orthogonal reagents, high yields at low concentrations, and the ease of eliminating excess reagents and by-products.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

The efficacy and safety of the drug delivery system are inadequate
The linker is unstable in blood circulation and has more side effects
The degradation rate of linkers is too slow, and the accumulation leads to toxicity in vivo
Complex PC cleavable linkers are difficult to synthesize
Cleavable linkers cannot break under mild conditions
It is difficult to remove excess reagents and by-products

Key features:

Key benefits:

Enhance the solubility of labeled molecules in aqueous medium
The structure does not affect the activity of other proteases
Rapid and complete rupture under mild conditions
Biodegradable, does not accumulate in the body toxic
Interact with or to manipulate the biological target
Suitable for in vitro and in vivo experiments
Ready-to-use

Application candidates:

Synthetic antibody-conjugated drugs
DNA sequencing
Be reactive groups for protein crosslinking, ligation or for click chemistry
Fluorescent probes for diagnostic tools, proteomic analysis or cell imaging
Tags for MS analysis or purification
Targeting molecules for functional proteomics or activity based probe profiling (ABPP)