pH-responsive copolymers have been extensively researched and utilized in drug delivery systems due to their ability to undergo changes in response to fluctuations in pH. These copolymers are designed to be stable at one pH range but become soluble, undergo swelling, or exhibit changes in shape or charge at a different pH range. This property allows for targeted and controlled drug release in specific environments of the body, such as tumor regions or the acidic environment of the stomach. pH-responsive copolymers in drug delivery offer a promising strategy for improving site-specific drug release, enhancing therapeutic efficacy, and minimizing off-target side effects.
CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:
The challenges you might meet:
Drug degradation or premature release
The toxicity of therapeutic drugs can cause damage to normal cells
The concentration of the drug at the tumor site is low
Tedious copolymers formulation, purifications, and production
Key benefits:
pH-Dependent Solubility/ Swelling: allows for controlled release of drugs based on the pH conditions of the target site
As the environmental pH reaches a specific threshold, the copolymer undergoes changes (e.g., solubilization, swelling, degradation) that facilitate the release of the encapsulated drug
Good stability and biocompatibility
Tailorable pH-Responsiveness: can be fine-tuned by adjusting its composition, molecular weight, and the proportion of pH-sensitive units in the polymer structure
Versatile Drug Loading: encapsulate a wide range of drugs, including hydrophobic, hydrophilic, and even macromolecular drugs
Suitable for in vitro and in vivo experiments
Ready-to-use
Application candidates:
Tissue Engineering Scaffolds: respond to the physiological pH of the surrounding tissues, undergoing controlled degradation or releasing bioactive molecules as needed to facilitate tissue regeneration
They enable targeted delivery to specific regions of the body, such as tumors with an acidic microenvironment, improving drug efficacy and reducing side effects
Biosensors and Bioimaging: to be incorporated into biosensing platforms or contrast agents for bioimaging applications
Used in the process of environmental remediation to selectively adsorb or release target pollutants according to pH conditions
