pH Response


pH-responsive copolymers have been extensively researched and utilized in drug delivery systems due to their ability to undergo changes in response to fluctuations in pH. These copolymers are designed to be stable at one pH range but become soluble, undergo swelling, or exhibit changes in shape or charge at a different pH range. This property allows for targeted and controlled drug release in specific environments of the body, such as tumor regions or the acidic environment of the stomach. pH-responsive copolymers in drug delivery offer a promising strategy for improving site-specific drug release, enhancing therapeutic efficacy, and minimizing off-target side effects.

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • Drug degradation or premature release
  • The toxicity of therapeutic drugs can cause damage to normal cells
  • The concentration of the drug at the tumor site is low
  • Tedious copolymers formulation, purifications, and production

Key benefits:

  • pH-Dependent Solubility/ Swelling: allows for controlled release of drugs based on the pH conditions of the target site
  • As the environmental pH reaches a specific threshold, the copolymer undergoes changes (e.g., solubilization, swelling, degradation) that facilitate the release of the encapsulated drug
  • Good stability and biocompatibility
  • Tailorable pH-Responsiveness: can be fine-tuned by adjusting its composition, molecular weight, and the proportion of pH-sensitive units in the polymer structure
  • Versatile Drug Loading: encapsulate a wide range of drugs, including hydrophobic, hydrophilic, and even macromolecular drugs
  • Suitable for in vitro and in vivo experiments
  • Ready-to-use

Application candidates:

  • Tissue Engineering Scaffolds: respond to the physiological pH of the surrounding tissues, undergoing controlled degradation or releasing bioactive molecules as needed to facilitate tissue regeneration
  • They enable targeted delivery to specific regions of the body, such as tumors with an acidic microenvironment, improving drug efficacy and reducing side effects
  • Biosensors and Bioimaging: to be incorporated into biosensing platforms or contrast agents for bioimaging applications
  • Used in the process of environmental remediation to selectively adsorb or release target pollutants according to pH conditions

DSPE-Hyd-PEG-Mal

Catalog: PHRC305

MW: N/A

mPEG-b-PAE

Catalog: PHRC3

MW: PAE10K, PEG5K

PAE-PEG (pH5.6 sensitive)

Catalog: PHRC8

MW: N/A

PAE-PEG-FA

Catalog: PHRC14

MW: PAE10K PEG5KE

PAE2k-PEG2k-FA

Catalog: PHRC10

MW: N/A

8arm-PEG-DBCO

Catalog: PHRC430

MW: N/A

AA-C6-PEG-hyd-DSPE

Catalog: PHRC445

MW: N/A

AA-PEG-hyd-DSPE

Catalog: PHRC444

MW: N/A

Alkyne-PEG750-Hyd-DSPE

Catalog: PHRC480

PEG MW: 750 Da

DA-Tat-PECL

Catalog: PHRC504

DA-Tat-PEG-PCL

Catalog: PHRC503

DOX-Hyd-AuNPs

Catalog: PHRC448

MW: N/A

DOX-hyd-PEG-FA

Catalog: PHRC442

MW: N/A

DOX-Hyd-PEG-NH2

Catalog: PHRC475

PEG MW: 1000 Da

DOX-HYD-PLGA

Catalog: PHRC438

MW: N/A

DSPE-HYD-mPEG Phospholipid

Catalog: PHRC307

MW: N/A

DSPE-Hyd-PEG-Alkyne

Catalog: PHRC453

PEG MW: 750 Da, 1000 Da, 2000 Da, 3400 Da, 5000 Da, 10000 Da

DSPE-Hyd-PEG-Alkyne

Catalog: PHRC431

MW: N/A

DSPE-Hyd-PEG-CHO

Catalog: PHRC454

PEG MW: 1000 Da, 2000 Da, 3400 Da, 5000 Da, 10000 Da

DSPE-Hyd-PEG-CHO

Catalog: PHRC433

MW: N/A

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