CD Bioparticles offers custom services to produce special drug delivery carrier by advanced bionanotechnology. Our experienced scientists have created a comprehensive platform to synthesize different bioparticles, provide control quality service. Among these bioparticles, pharmacosome is one of the enormous potential drug carrier systems.
Introduction to Pharmacosomes
Pharmacosomes are colloidal dispersions made of amphiphilic phospholipids which could be complexed with drugs via hydrogen bonds between active hydrogens and phospholipids. Pharmacosomes may exist as ultrafine vesicular, micellar, or hexagonal aggregates, depending on the chemical structure of drug-lipid complex. It is based on the principle that the drug binds covalently to a lipid where the resulting compound is the carrier and the active compound at the same time. The physicochemical properties depend on the drug as well as the lipid. They are mainly prepared by hand-shaking and ether injection method. Pharmacosomes have advantages over liposomal, transferosomal, and niosomal drug delivery systems. They minimize drug degradation and increase the bioavailability of poorly soluble drugs, suitable for both hydrophilic and lipophilic drugs. More importantly, the entrapment efficiency is not only high but predetermined.
Figure 1. Forms and component of pharmacosomes (Ujjwala B, et al. Pharmacosomes: A Novel Drug Delivery System. International Journal of Pharmaceutical Research & Allied Sciences.2014, 3(1): 14-20.)
Pharmacosomes can be applied widely by different routes of delivery via oral, topically, or through extravascular and intravascular routes. Since pharmacosomes could enhance the solubility for both hydrophilic and lipophilic drugs in the delivery system, it provides a good approach to increase the bioavailability of poorly soluble drugs. There has been an advancement in the scope of this delivery system for a number of drugs used for inflammation, heart diseases, cancer, and protein delivery along with a large number of herbal drugs. Because of its amphiphilicity, new challenges and opportunities are arising for improved novel vesicular drug delivery system.
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1. P. H. Sharma, P. V. Powar, S. S. Sharma. Pharmacosomes: A novel drug delivery system. The Pharma Innovation Journal. 2014, 3(10): 94-100.
2. Ujjwala B, et al. Pharmacosomes: A Novel Drug Delivery System. International Journal of Pharmaceutical Research & Allied Sciences.2014, 3(1): 14-20.
3. Tanu G, Ashwini S. R, Meenakshi C. Pharmacosomes: opening new doors for drug delivery. International Journal of Pharmacy and Pharmaceutical Sciences. 2012, 4:25-29.
4. De pintu kumar, De arnab, pharmacosomes: a potential vascular drug delivery system. International research journal of pharmacy. 2012,102-105.