Porous Organic Materials

CD Bioparticles' products feature customized delivery strategies, precise design and modification of drugs or drug-containing cargoes, and advanced technology platforms that can help you address:

The challenges you might meet:

  • Cumbersome chemical synthesis, formulation and purification
  • Lack of reliable raw materials for further synthesis of novel porous organic materials
  • Nanomedicine lacks cell-specific or tissue-specific targeting
  • Difficult to add functional groups required for drug carrier delivery
  • Difficulty tracking and imaging the distribution of polymer-based (nano) materials
  • Limited drug loading efficiency and yield of drug delivery materials
  • Your carrier material has a strong immune or foreign body reaction
  • Low cellular uptake of nano-drug delivery systems
  • Uncontrolled drug release

Porous Organic Materials Key Features:

  • RAFT Reagents

  • MOF Initiators

  • Functional Materials

    • g-C3N4

    • Ionic Liquids

    • Optoelectronic Materials

    • Optoelectronic Materials Intermediates

  • Catalyst & Ligands

  • Metal-organic Frameworks (MOFs) Linkers

    • Multi-Carboxylic MOFs Linkers

    • 2d-Carboxylic MOFs Linkers

    • 3d-Carboxylic MOFs Linkers

    • 4d-Carboxylic MOFs Linkers

    • Multi-Nitrogen MOFs Linkers

    • 2d-Nitrogen MOFs Linkers

    • 3d-Nitrogen MOFs Linkers

    • Multi-Hybrid MOFs Linkers

    • 2d-Hybrid MOFs Linkers

    • 3d-Hybrid MOFs Linkers

    • A2B2-Porphyrins

    • A3B1-Porphyrins

    • A4-Porphyrins

    • Bipyridine Blocks

    • Halide Substituted Aromatics

    • Metalloporphyrins

    • Tetraphenylethylene

    • Triphenylbenzene

    • Customizable MOFs Linkers

    • Isophthalate

    • Other MOFs Linkers

    • Other Organic-Linker Blocks

  • Covalent Organic Framework (COFs) Linkers

    • Multi-Nitrile COFs Linkers

    • 2d Boric COFs Linkers

    • 3d-Boric COFs Linkers

    • 4d-Boric COFs Linkers

    • 2d Nitrile COFs Linkers

    • 3d Nitrile COFs Linkers

    • Acetonitrile COFs Linkers

    • Multi-Aldehyde COFs Linkers

    • 2d-Aldehyde COFs Linkers

    • 3d-Aldehyde COFs Linkers

    • Multi-Alkyne Orgnic COFs Linkers

    • 2d-Alkyne Orgnic COFs Linkers

    • 3d-Alkyne Orgnic COFs Linkers

    • Multi-Phosphoric Acids COFs Linkers

    • 2d-Phosphoric Acids COFs Linkers

    • 3d-Phosphoric Acids COFs Linkers

    • Multi-Amine COFs Linkers

    • 2d-Amine COFs Linkers

    • Hybrid COFs Linkers

    • Customizable COFs Linkers

    • Other COFs Linkers

  • Metal-organic Frameworks (MOFs) Materials

    • Iron-based MOFs (Fe-MOF)

    • Zinc-Based MOFs (Zn-MOF)

    • Cerium-based MOFs (Ce-MOF)

    • Cobalt-based MOFs (Co-MOF)

    • Nickel-based MOFs (Ni-MOF)

    • Indium-based MOFs (In-MOF)

    • Vanadium-based MOFs (V-MOF)

    • Titanium-based MOFs (Ti-MOF)

    • Chromium-based MOFs (Cr-MOF)

    • Aluminum-based MOFs (Al-MOF)

    • Copper-based MOFs (Cu–MOF)

    • Manganese-based MOFs (Mn-MOF)

    • Magnesium-based MOFs (Mg-MOF)

    • Zirconium-based MOFs (Zr-MOF)

  • Covalent Organic Framework (COF) Materials

  • Hydrogen-bonded Organic Framework (HOF) Materials

Porous Organic Materials Key Benefits:

  • Broad coverage of porous organic materials with functional groups/targeting ligands/labels for loading, modification, specific targeting, tracking and detection
  • Provide porous organic materials with different properties through the modification of inorganic clusters and/or organic ligands
  • Improve biocompatibility, activity and functional properties of porous organic materials
  • Flexibility to use surface adsorption, pore encapsulation, covalent binding or functional molecular building blocks to load drug molecules
  • Synthesis of biodegradable porous organic materials using moderately strong coordination bonds
  • Manufacture from non-GMP small laboratory scale to GMP and non-GMP grade commercial scale

Porous Organic Materials Application Candidates:

  • Drug delivery system carriers: The synthesis, characterization, and drug-related studies of low-toxicity, biocompatible porous organic materials suggest that they can be used for in vivo drug delivery. At the same time, various methods can be designed to induce drug release from porous organic materials, such as pH-responsive, magnetic-responsive, ionic-responsive, temperature-responsive, and pressure-responsive.
  • Bionic mineralization: By incorporating biomolecules (including proteins, DNA, and antibodies) during the crystallization of porous organic materials, biomolecules encapsulated in this way are stable and active even when exposed to harsh conditions such as corrosive solvents and high temperatures.
  • Fabrication of biocompatible porous organic materials
  • Bioimaging and Sensing
  • Sorbent
  • Catalyst
  • Desalination/Ion Separation
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