Covalent Organic Framework (COFs) Linkers

The design idea of ​​covalent organic framework materials (COFs) originates from the concept of framework chemistry. It is a systematic framework material design theory based on the basic theory of geometric space topology of secondary building units. In recent years, this theory has successfully expanded from metal-organic framework materials to the category of pure organic polymers, and has greatly promoted the development of covalent organic framework materials. Compared with traditional inorganic porous materials, covalent organic framework materials have a significant advantage in that they have good structural tailorability and functional tunability. Since the boron-containing COF was first synthesized in 2005, the development of COFs materials has progressed by leaps and bounds. Its topological structure has expanded from zero-dimensional to three-dimensional, from amorphous to crystalline, and the pore size has ranged from microporous to mesoporous. More and more COFs materials have been Discover. There are mainly boron-containing COFs materials, imine-based COFs materials, triazine-based COFs materials and other types of COFs materials. Due to its high thermochemical stability, large specific surface area and porosity, controllable chemical and physical properties, low skeleton density, permanently open pore structure and diversified synthesis strategies, COFs materials have great application in catalytic technology, it has important application prospects in many fields such as gas separation and storage, optoelectronic materials, drug delivery, environment and energy.

Fabrication of azo-linked COFs via linker exchange. (Zhi-Bei Zhou, et al. 2022)Figure 1. Fabrication of azo-linked COFs via linker exchange. (Zhi-Bei Zhou, et al.; 2022)

The application of COFs in the biomedical field is one of its emerging applications, and one of the most prominent applications is drug encapsulation/decapsulation. Some drug molecules have problems such as low biological stability and poor tumor targeting. These problems can be overcome by using targeted COFs as delivery cargo. Another application of COFs in the biomedical field is photodynamic therapy (PDT), a minimally invasive treatment method in which COFs are loaded with multifunctional photosensitizers. They then absorb light and are excited by oxygen to form reactive oxygen species, which ultimately leads to cancer cell death. In addition, photothermal therapy (PTT) is another important application of COFs, in which the photothermal agents in COFs absorb radiation in the near-infrared range. The excited state energy of the photothermal agent is dissipated in the form of heat through non-radiative relaxation, which ultimately increases the cell temperature and damages the cells.

To this end, CD Bioparticles manufactures and supplies COF linkers for COF synthesis. They can help you solve some challenges.

The challenges you might meet:

  • Lack of carriers with high drug loading capacity
  • Lack of precise control of drug release rate
  • Lack of drug delivery vehicles that target specific cell types or tissues
  • Drugs developed lack chemical stability
  • Need for delivery systems that can serve multiple functions
  • Drugs are limited due to their low solubility
  • Drug delivery systems with high biocompatibility are needed

COFs linkers products key features:

COFs linkers products key benefits:

  • Modular and tunable structure that can be used for fluorescence imaging or combined with target structures
  • Intrinsic pores can be used to upload guest molecules, such as drug molecules
  • The structural geometric parameters and topology of COFs can be adjusted so that COFs have a variety of optical properties.
  • Compared to MOFs, COFs are inherently metal-free and therefore do not have concerns about potential biotoxicity caused by metal ion leaching

COFs linkers products application candidates:

  • Tumor Targeted Drug Delivery
  • Adsorption and separation
  • Photodynamic therapy (PDT)
  • Photothermal therapy (PTT)
  • Drug encapsulation/decapsulation
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