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-S-S- Cleavable Linkers


Recently, -S-S- reduction sensitive nanoparticles have attracted a lot of interest to address the problem of fast drug release in cells. Such nanoparticles typically consist of a drug-loaded core and a hydrophilic shell, introducing disulfide bonds into the carrier backbone, side chains, or crosslinkers. Disulfide bond can exist stably outside the cell, but when the nanoparticles enter into the tumor cells, they can exchange disulfide bond with the high concentration of glutathione (GSH) in the cytoplasm, resulting in the disulfide bond breaking and the destruction of the carrier structure, so as to achieve the purpose of rapid drug release. Disulfide bond breakage can occur not only in the cytoplasm, but also in lysosomes, due to the presence of gamma-interferon-induced lysosomal mercaptan (GILT), which can reduce disulfide bonds.

-S-S- Cleavable Linkers

Fmoc-NH-ethyl-SS-propionic acid

Catalog: CDAX067

MW: 403.51

$930
-S-S- Cleavable Linkers

Azidoethyl-SS-propionic NHS ester

Catalog: CDAX118

MW: 304.34

$1180
-S-S- Cleavable Linkers

Azidoethyl-SS-ethylazide

Catalog: CDAX120

MW: 204.27

$760
-S-S- Cleavable Linkers

Azidoethyl-SS-ethylamine

Catalog: CDAX121

MW: 178.27

$1160
-S-S- Cleavable Linkers

Aminoethyl-SS-ethylamine

Catalog: CDAX126

MW: 152.27

$610
-S-S- Cleavable Linkers

Acid-PEG3-SS-PEG3-acid

Catalog: CDAX135

MW: 474.58

$1380
-S-S- Cleavable Linkers

THP-SS-PEG1-Tos

Catalog: CDAX010

MW: 392.54

$690
-S-S- Cleavable Linkers

THP-SS-PEG1-t-butyl ester

Catalog: CDAX011

MW: 366.53

$760
-S-S- Cleavable Linkers

THP-SS-alcohol

Catalog: CDAX012

MW: 238.36

$690
-S-S- Cleavable Linkers

t-Boc-Cystamine

Catalog: CDAX016

MW: 252.39

$1240
-S-S- Cleavable Linkers

Sulfo-NThiol-SS-biotin

Catalog: CDAX017

MW: 606.67

$760
-S-S- Cleavable Linkers

Propargyl-PEG1-SS-PEG1-t-butyl ester

Catalog: CDAX020

MW: 320.46

$820
-S-S- Cleavable Linkers

Propargyl-PEG1-SS-PEG1-propargyl

Catalog: CDAX021

MW: 230.34

$960
-S-S- Cleavable Linkers

Propargyl-PEG1-SS-PEG1-PFP ester

Catalog: CDAX022

MW: 430.4

$980
-S-S- Cleavable Linkers

Propargyl-PEG1-SS-PEG1-acid

Catalog: CDAX023

MW: 264.35

$980
-S-S- Cleavable Linkers

Propargyl-PEG1-SS-alcohol

Catalog: CDAX024

MW: 192.29

$1130
-S-S- Cleavable Linkers

NThiol-SS-biotin

Catalog: CDAX037

MW: 504.64

$820
-S-S- Cleavable Linkers

m-PEG6-SS-PEG6-methyl

Catalog: CDAX041

MW: 622.83

$1020
-S-S- Cleavable Linkers

Mal-NH-ethyl-SS-propionic acid

Catalog: CDAX056

MW: 332.39

$930
-S-S- Cleavable Linkers

Hydroxy-PEG3-SS-PEG3-alcohol

Catalog: CDAX060

MW: 418.56

$1020
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